Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/58248

TítuloNuclear migration in mammalian brain development
Autor(es)Bertipaglia, Chiara
Gonçalves, João Carlos
Vallee, Richard Bert
Palavras-chaveCentrosome
Cytoskeleton
Microtubules
Migration
Molecular motors
Nuclear envelope
Nucleus
DataOut-2018
EditoraElsevier Ltd
RevistaSeminars in Cell and Developmental Biology
Resumo(s)During development of the mammalian brain, neural stem cells divide and give rise to adult stem cells, glia and neurons, which migrate to their final locations. Nuclear migration is an important feature of neural stem cell (radial glia progenitor) proliferation and subsequent postmitotic neuronal migration. Defects in nuclear migration contribute to severe neurodevelopmental disorders such as microcephaly and lissencephaly. In this review, we address the cellular and molecular mechanisms responsible for nuclear migration during the radial glia cell cycle and postmitotic neuronal migration, with a particular focus on the role of molecular motors and cytoskeleton dynamics in regulating nuclear behavior.
TipoArtigo
URIhttps://hdl.handle.net/1822/58248
DOI10.1016/j.semcdb.2017.11.033
ISSN1084-9521
Arbitragem científicayes
AcessoAcesso aberto
Aparece nas coleções:ICVS - Artigos em revistas internacionais / Papers in international journals

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