Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58248
Título: | Nuclear migration in mammalian brain development |
Autor(es): | Bertipaglia, Chiara Gonçalves, João Carlos Vallee, Richard Bert |
Palavras-chave: | Centrosome Cytoskeleton Microtubules Migration Molecular motors Nuclear envelope Nucleus |
Data: | Out-2018 |
Editora: | Elsevier Ltd |
Revista: | Seminars in Cell and Developmental Biology |
Resumo(s): | During development of the mammalian brain, neural stem cells divide and give rise to adult stem cells, glia and neurons, which migrate to their final locations. Nuclear migration is an important feature of neural stem cell (radial glia progenitor) proliferation and subsequent postmitotic neuronal migration. Defects in nuclear migration contribute to severe neurodevelopmental disorders such as microcephaly and lissencephaly. In this review, we address the cellular and molecular mechanisms responsible for nuclear migration during the radial glia cell cycle and postmitotic neuronal migration, with a particular focus on the role of molecular motors and cytoskeleton dynamics in regulating nuclear behavior. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58248 |
DOI: | 10.1016/j.semcdb.2017.11.033 |
ISSN: | 1084-9521 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Bertipaglia.pdf | 2,83 MB | Adobe PDF | Ver/Abrir |