Chitosan/soy-based membranes enhance wound reepithelialization in partial thickness skin wounds

Abstract

[Excerpt] Chitosan-based biomaterials proved to have promising characteristics for wound dressing and skin regeneration. In the context of developing new natural-based biomaterials for these applications, chitosan and soybean-based biomaterials were proposed. These materials were shown to be non cytotoxic and to impair human leukocytes activation in vitro. Thus the goal of this study was to evaluate the in vivo performance of chitosan/soy-based membranes in the regeneration of partial thickness skin wounds. Excisional skin wounds were created on the backs of rats and the healing capacity of chitosan/soy-based membranes was assessed after 1 and 2 weeks. To promote impaired wound healing all rats were injected with a steroid. [...]