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https://hdl.handle.net/1822/59525
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Monteiro, Rodrigo | por |
dc.contributor.author | Pires, Diana Priscila Penso | por |
dc.contributor.author | Costa, Ana Rita Martins | por |
dc.contributor.author | Azeredo, Joana | por |
dc.date.accessioned | 2019-03-18T09:56:21Z | - |
dc.date.available | 2019-03-18T09:56:21Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Monteiro, Rodrigo; Pires, Diana P.; Costa, Ana Rita; Azeredo, Joana, Phage Therapy: Going Temperate?. Trends in Microbiology, 27(4), 368-378, 2018. | por |
dc.identifier.issn | 0966-842X | por |
dc.identifier.uri | https://hdl.handle.net/1822/59525 | - |
dc.description.abstract | Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction â an event that may increase bacterial virulence, for example, by promoting antibiotic resistance. Now, advances in sequencing technologies and synthetic biology are providing new opportunities to explore the use of temperate phages for therapy against bacterial infections. By doing so we can considerably expand our armamentarium against the escalating threat of antibiotic-resistant bacteria. | por |
dc.description.sponsorship | This work was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the project PTDC/BBB-BSS/6471/2014 (POCI-01-0145-FEDER-016678), the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684). This work was also supported by BioTecNorte operation (NORTE-01- 0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020–Programa Operacional Regional do Norte. ARC and DPP were supported by FCT grants SFRH/BPD/94648/2013 and SFRH/BPD/ 116187/2016, respectively. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | PTDC/BBB-BSS/6471/2014 | - |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F94648%2F2013/PT | - |
dc.relation | SFRH/BPD/116187/2016 | - |
dc.rights | openAccess | por |
dc.subject | Phage therapy | por |
dc.subject | Temperate phages | por |
dc.subject | Synthetic biology | por |
dc.subject | Antibiotic resistance | por |
dc.subject | CRISPR-Cas | por |
dc.title | Phage therapy: going temperate? | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.cell.com/trends/microbiology/home | por |
dc.comments | CEB49200 | por |
oaire.citationStartPage | 368 | por |
oaire.citationEndPage | 378 | por |
oaire.citationIssue | 4 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 27 | por |
dc.date.updated | 2019-03-17T17:42:42Z | - |
dc.identifier.doi | 10.1016/j.tim.2018.10.008 | por |
dc.identifier.pmid | 30466900 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Trends in Microbiology | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_49200_1.pdf | 2,08 MB | Adobe PDF | Ver/Abrir |