Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/60016
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Rodrigues, Raquel O. | por |
dc.contributor.author | Baldi, Giovanni | por |
dc.contributor.author | Doumett, Saer | por |
dc.contributor.author | Gallo, Juan | por |
dc.contributor.author | Bañobre-López, Manuel | por |
dc.contributor.author | Dražić, Goran | por |
dc.contributor.author | Calhelha, Ricardo C. | por |
dc.contributor.author | Ferreira, Isabel C. F. R. | por |
dc.contributor.author | Lima, Rui Alberto Madeira Macedo | por |
dc.contributor.author | Silva, Adrián M. T. | por |
dc.contributor.author | Gomes, Helder T. | por |
dc.date.accessioned | 2019-04-12T11:26:59Z | - |
dc.date.available | 2019-04-12T11:26:59Z | - |
dc.date.issued | 2018-10-13 | - |
dc.identifier.issn | 2311-5629 | - |
dc.identifier.uri | https://hdl.handle.net/1822/60016 | - |
dc.description.abstract | A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer. | por |
dc.description.sponsorship | This research was funded by Project POCI-01-0145-FEDER-006984 - Associate Laboratory LSRE-LCM funded by FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) - and by national funds through FCT - Fundação para a Ciência e a Tecnologia, and by project NORTE-01-0145-FEDER-029394, RTChip4Theranostics, supported by Programa Operacional Regional do Norte - Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by Fundação para a Ciência e Tecnologia (FCT), IP. | por |
dc.description.sponsorship | R.O.R. acknowledges the Ph.D. scholarship SFRH/BD/97658/2013 granted by FCT. G.D. acknowledges financing by Slovene Research Agency (J2-6754). The authors also would like to acknowledge the financial support provided by COST—European Cooperation in Science and Technology, in the form of a short term scientific mission (STSM) granted by COST Action TD1402: RADIOMAG. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F97658%2F2013/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | graphene magnetic nanocomposites | por |
dc.subject | drug delivery | por |
dc.subject | DOX cancer | por |
dc.title | A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 4 | por |
dc.date.updated | 2019-04-11T11:06:23Z | - |
dc.identifier.doi | 10.3390/c4040055 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | C | por |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
carbon-04-00055.pdf | 3,34 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons