Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61266
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Rodrigues, Célia F. | por |
dc.contributor.author | Rodrigues, M. Elisa | por |
dc.contributor.author | Henriques, Mariana | por |
dc.date.accessioned | 2019-09-02T10:02:04Z | - |
dc.date.available | 2019-09-02T10:02:04Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Rodrigues, Célia F.; Rodrigues, M. Elisa; Henriques, Mariana, Promising alternative therapeutics for oral candidiasis. Current Medicinal Chemistry, 26(14), 2515-2528, 2019 | por |
dc.identifier.issn | 09298673 | por |
dc.identifier.uri | https://hdl.handle.net/1822/61266 | - |
dc.description.abstract | Candida is the main human fungal pathogen causing infections (candidiasis), mostly in the elderly and immunocompromised hosts. Even though Candida spp. is a member of the oral microbiota in symbiosis, in some circumstances, it can cause microbial imbalance leading to dysbiosis, resulting in oral diseases. Alternative therapies are urgently needed to treat oral candidiasis (usually associated to biofilms), as several antifungal drugs activity has been compromised. This has occurred especially due to an increasing occurrence of drugresistant in Candida spp. strains. The overuse of antifungal medications, systemic toxicity, cross-reactivity with other drugs and a presently low number of drug molecules with antifungal activity, have contributed to important clinical limitations. We undertook a structured search of bibliographic databases (PubMed Central, Elseviers ScienceDirect, SCOPUS and Springers SpringerLink) for peer-reviewed research literature using a focused review in the areas of alternatives to manage oral candidiasis. The keywords used were candidiasis, oral candidiasis, biofilm + candida, alternative treatment, combination therapy + candida and the reports from the last 10 to 15 years were considered for this review. This review identified several promising new approaches in the treatment of oral candidiasis: combination anti-Candida therapies, denture cleansers, mouth rinses as alternatives for disrupting candidal biofilms, natural compounds (e.g. honey, probiotics, plant extracts and essential oils) and photodynamic therapy. The findings of this review confirm the importance and the urgency of the development of efficacious therapies for oral candidal infections | por |
dc.description.sponsorship | This study was supported by the Portuguese Foun- dation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER- 006684) and BioTecNorte operation (NORTE-01- 0145-FEDER-000004) funded by the European Re- gional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte and Célia F. Rodrigues’ [SFRH/BD/93078/2013] PhD grant and M. Elisa Rodrigues’ [SFRH/BPD/95401/2013] post-doc grant. C.F.R. also would like to thank the project UID/EQU/00511/2019-Laboratory for Process Engineering, Environment, Biotechnology and EnergyLEPABE funded by national funds through FCT/MCTES (PIDDAC). Célia F. Rodrigues also thank the project UID/EQU/00511/2019-Laboratory for Process Engineering, Environment, Biotechnology and Energy-LEPABE funded by national funds through FCT/MCTES (PIDDAC). | por |
dc.language.iso | eng | por |
dc.publisher | Bentham Science Publishers | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F93078%2F2013/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F95401%2F2013/PT | por |
dc.relation | UID/EQU/00511/2019 | por |
dc.rights | openAccess | por |
dc.subject | Candida | por |
dc.subject | oral candidiasis | por |
dc.subject | resistance | por |
dc.subject | antifungal treatment | por |
dc.subject | plants | por |
dc.subject | honey | por |
dc.subject | probiotics | por |
dc.subject | photodynamic therapy | por |
dc.title | Promising alternative therapeutics for oral candidiasis | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://benthamscience.com/journals/current-medicinal-chemistry/ | por |
dc.comments | CEB51950 | por |
oaire.citationStartPage | 2515 | por |
oaire.citationEndPage | 2528 | por |
oaire.citationIssue | 14 | por |
oaire.citationVolume | 26 | por |
dc.date.updated | 2019-09-02T09:04:45Z | - |
dc.identifier.eissn | 1875533X | por |
dc.identifier.doi | 10.2174/0929867325666180601102333 | por |
dc.identifier.pmid | 29852856 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Current Medicinal Chemistry | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_51950_1.pdf | 811,41 kB | Adobe PDF | Ver/Abrir |