Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61458
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Cerqueira, João José | por |
dc.contributor.author | Almeida, Osborne F. X. | por |
dc.contributor.author | Sousa, Nuno | por |
dc.date.accessioned | 2019-09-23T12:49:41Z | - |
dc.date.available | 2019-09-23T12:49:41Z | - |
dc.date.issued | 2008-07 | - |
dc.identifier.issn | 0889-1591 | - |
dc.identifier.uri | https://hdl.handle.net/1822/61458 | - |
dc.description.abstract | The prefrontal cortex (PFC) plays an important role in the integration of cognitive and affective behavior and regulating autonomic and neuroendocrine functions. This region of the brain, which may be considered analogous to the RAM memory of a computer, is important for translating stressful experience into adaptive behavior. The PFC responds to stress and modulates the response to stress through regulation of the hypothalamic paraventricular nucleus (PVN) which, in turn, controls sympathoadrenal and hypothalamic-pituitary-adrenal (HPA) activity. Interestingly, the latter convey the signals that link the CNS with the immune system. The present review highlights findings that contribute to elucidate the involvement of the PFC in the control of behavioral and neuroendocrine responses to chronic stress. It also considers the implications of these regulatory links for disorders of the nervous and immune systems. | por |
dc.description.sponsorship | Authors’ work was in part supported by grants from the Portuguese J.J. Cerqueira et al. / Brain, Behavior, and Immunity 22 (2008) 630–638 635 government Foundation for Science and Technology (FCT)—Project PTDC/SAU-NEU/72699/2006—and Calouste Gulbenkian Foundation—Project JG/0495. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/72699/PT | por |
dc.rights | openAccess | por |
dc.subject | Adaptation, Psychological | por |
dc.subject | Animals | por |
dc.subject | Functional Laterality | por |
dc.subject | Humans | por |
dc.subject | Hypothalamo-Hypophyseal System | por |
dc.subject | Neurosecretory Systems | por |
dc.subject | Paraventricular Hypothalamic Nucleus | por |
dc.subject | Pituitary-Adrenal System | por |
dc.subject | Prefrontal Cortex | por |
dc.subject | Stress, Psychological | por |
dc.subject | HPA axis | por |
dc.subject | Hippocampus | por |
dc.subject | Handedness | por |
dc.subject | Hemispheric asymmetry | por |
dc.subject | Lateralization | por |
dc.subject | Immune response | por |
dc.subject | Autonomic nervous system | por |
dc.subject | stress | por |
dc.title | The stressed prefrontal cortex. Left? Right! | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 630 | por |
oaire.citationEndPage | 638 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 22 | por |
dc.identifier.eissn | 1090-2139 | - |
dc.identifier.doi | 10.1016/j.bbi.2008.01.005 | por |
dc.identifier.pmid | 18281193 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Brain, Behavior, and Immunity | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Cerqueira-2008-The-stressed-prefrontal-cortex-left.pdf | 594,12 kB | Adobe PDF | Ver/Abrir |