Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61604
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Macedo, Francisco Yuri Bulcao | por |
dc.contributor.author | Baltazar, Fátima | por |
dc.contributor.author | Almeida, Paulo Roberto Carvalho | por |
dc.contributor.author | Távora, Fábio | por |
dc.contributor.author | Ferreira, Francisco Valdeci | por |
dc.contributor.author | Schmitt, Fernando C. | por |
dc.contributor.author | Brito, Gerly Anne Castro | por |
dc.contributor.author | Ribeiro, Ronaldo Albuquerque | por |
dc.date.accessioned | 2019-10-04T11:19:42Z | - |
dc.date.issued | 2008-01 | - |
dc.identifier.issn | 0171-5216 | - |
dc.identifier.uri | https://hdl.handle.net/1822/61604 | - |
dc.description.abstract | Purpose Hemorrhagic cystitis (HC) is a limiting side effect of chemotherapy with ifosfamide (IFS). In this study, we investigated the participation of cyclooxygenase-2 (COX-2) upon ifosfamide-induced HC. Methods Male Wistar rats (150-200 g; six rats per group) were treated with saline, IFS (400 mg/kg, i.p.) and analyzed by changes in bladder wet weight, macroscopic and microscopic parameters, and COX-2 expression. In other groups etoricoxib (selective COX-2 inhibitor), indomethacin (non-selective COX inhibitor), thalidomide (selective TNF-alpha inhibitor), pentoxifyllin (non-selective TNF-alpha inhibitor) were added 1 h before IFS administration. The classical protocol using three doses of Mesna was also evaluated and compared with two extra doses of etoricoxib or indomethacin. Results COX-2 was expressed significantly 24 h after IFS administration mainly in myofibroblasts and mast cells evaluated by immunohistochemistry. Treatment 1 h before IFS injection with etoricoxib, indomethacin, thalidomide, and pentoxifylline reduced COX-2 expression and some macroscopic and microscopic parameters in IFS-induced HC. Moreover, addition of etoricoxib or indomethacin with the last two doses of Mesna was more efficient than three doses of Mesna alone when evaluated microscopically. Conclusions COX-2 participates in the pathogenesis of IFS-induced HC and the treatment with COX and TNF-alpha inhibitors reduced COX-2 expression. The addition of COX-inhibitors to the last two doses of Mesna represents a new therapeutic strategy of preventing HC. | por |
dc.description.sponsorship | National Research Council of Brazil (CNPq), CAPES and Fundação Cearense de Amparo a Pesquisa (FUNCAP), Ceará-Brazil, for financial support. | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.rights | restrictedAccess | por |
dc.subject | Animals | por |
dc.subject | Cyclooxygenase 2 | por |
dc.subject | Cyclooxygenase 2 Inhibitors | por |
dc.subject | Cystitis | por |
dc.subject | Drug Therapy, Combination | por |
dc.subject | Etoricoxib | por |
dc.subject | Hemorrhage | por |
dc.subject | Ifosfamide | por |
dc.subject | Immunoenzyme Techniques | por |
dc.subject | Indomethacin | por |
dc.subject | Male | por |
dc.subject | Mesna | por |
dc.subject | Pentoxifylline | por |
dc.subject | Protective Agents | por |
dc.subject | Pyridines | por |
dc.subject | Rats | por |
dc.subject | Rats, Wistar | por |
dc.subject | Sulfones | por |
dc.subject | Thalidomide | por |
dc.subject | Hemorrhagic cystitis | por |
dc.subject | TNF-alfa | por |
dc.subject | Myofibroblasts | por |
dc.subject | TNF-alpha | por |
dc.title | Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 19 | por |
oaire.citationEndPage | 27 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 134 | por |
dc.identifier.eissn | 1432-1335 | - |
dc.identifier.doi | 10.1007/s00432-007-0237-6 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 17638016 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Cancer Research and Clinical Oncology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Macedo-2007-Cyclooxygenase--expression-on-ifosf.pdf Acesso restrito! | 699,3 kB | Adobe PDF | Ver/Abrir |