Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62064
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Miranda-Gonçalves, Vera | por |
dc.contributor.author | Reis, R. M. | por |
dc.contributor.author | Baltazar, Fátima | por |
dc.date.accessioned | 2019-11-13T11:03:50Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Miranda-Gonçalves, V., M Reis, R., & Baltazar, F. (2016). Lactate transporters and ph regulation: potential therapeutic targets in glioblastomas. Current cancer drug targets, 16(5), 388-399 | por |
dc.identifier.issn | 1568-0096 | - |
dc.identifier.uri | https://hdl.handle.net/1822/62064 | - |
dc.description.abstract | Despite advances in therapy, glioblastoma (GBM) is still the most prevalent and lethal brain tumor. Thus, it is imperative to identify new and effective therapies that could improve the lifetime of these patients. It is known that tumor cells, such as glioblastomas present metabolic reprogramming, named "Warburg effect", recognized nowadays as a hallmark of cancer. This mechanism is associated with a high dependence of tumor cells on the glycolytic metabolism to sustain energy demands and macromolecule synthesis, leading to production of high amounts of lactic and carbonic acids. These metabolic products induce microenvironment acidification, due to up-regulation of several proteins, such as monocarboxylate transporters (MCTs) and carbonic anhydrases (CAs), to maintain the glycolytic phenotype and the intracellular physiological pH. The dependence on glycolytic metabolism and acidic microenvironment on the acquired resistance to standard therapy has been a research focus in glioblastoma therapy response. In this review, we intend to highlight evidence for the importance of lactate transporters and other pH regulators in GBMs, which are frequently overexpressed in GBMs and associated with tumor aggressiveness. Moreover, we will describe how targeting these proteins could constitute new therapeutic strategies to overcome glioma resistance to therapy. | por |
dc.description.sponsorship | Research was partially supported by MCTI/CNPq No 73/2013 (Brazil), and by Fundacao para a Ciencia e Tecnologia (FCT), Projecto Estrategico- LA 26 - 2013-2014 (PEst-C/SAL/LA0026/2013), Fundo Europeu de Desenvolvimento Regional (FEDER), through COMPETE (FCOMP-01-0124-FEDER-037298) and Project " ON.2 SR&TD Integrated Program (NORTE-07-0124-FEDER-000017)" co-funded by Programa Operacional Regional do Norte (ON.2- O Novo Norte), Quadro de Referencia Estrategico Nacional (QREN), through Fundo Europeu de Desenvolvimento Regional (FEDER), and by the Life and Health Sciences Research Institute (ICVS), University of Minho, Portugal, and Fundacao para a Ciencia e Tecnologia (FCT) SFRH/BD/51997/2012 to V. M. G. Vera Miranda-Goncalves wrote the manuscript and designed the pictures. Rui Manuel Reis and Fatima Baltazar participated in the conception of the manuscript and revision. | por |
dc.language.iso | eng | por |
dc.publisher | Bentham Science Publishers | por |
dc.rights | closedAccess | por |
dc.subject | Animals | por |
dc.subject | Brain Neoplasms | por |
dc.subject | Carbonic Anhydrases | por |
dc.subject | Glioblastoma | por |
dc.subject | Glycolysis | por |
dc.subject | Humans | por |
dc.subject | Hydrogen-Ion Concentration | por |
dc.subject | Lactic Acid | por |
dc.subject | Monocarboxylic Acid Transporters | por |
dc.subject | Up-Regulation | por |
dc.subject | Acidic microenvironment | por |
dc.subject | Lactate | por |
dc.subject | pH regulators | por |
dc.subject | Warburg effect | por |
dc.subject | carbonic anhydrases (CAs) | por |
dc.subject | glioblastomas | por |
dc.subject | monocarboxylate transporters (MCTs) | por |
dc.title | Lactate Transporters and pH Regulation: Potential Therapeutic Targets in Glioblastomas | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.eurekaselect.com/138023/article | por |
oaire.citationStartPage | 388 | por |
oaire.citationEndPage | 399 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 16 | por |
dc.identifier.eissn | 1873-5576 | - |
dc.identifier.doi | 10.2174/1568009616666151222150543 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 26694251 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Current Cancer Drug Targets | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
0003U.pdf Acesso restrito! | 4,97 MB | Adobe PDF | Ver/Abrir |