Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62068
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Campo DC | Valor | Idioma |
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dc.contributor.author | Moreira, Diana Raquel Bento | por |
dc.contributor.author | Silvestre, Ricardo Jorge Leal | por |
dc.contributor.author | Cordeiro-da-Silva, Anabela | por |
dc.contributor.author | Estaquier, Jérôme | por |
dc.contributor.author | Foretz, Marc | por |
dc.contributor.author | Viollet, Benoit | por |
dc.date.accessioned | 2019-11-13T12:04:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Moreira, D., Silvestre, R., Cordeiro-Da-Silva, A., Estaquier, J., Foretz, M., & Viollet, B. (2016). AMP-activated protein kinase as a target for pathogens: friends or foes?. Current drug targets, 17(8), 942-953 | por |
dc.identifier.issn | 1389-4501 | - |
dc.identifier.uri | https://hdl.handle.net/1822/62068 | - |
dc.description.abstract | Intracellular pathogens are known to manipulate host cell regulatory pathways to establish an optimal environment for their growth and survival. Pathogens employ active mechanisms to hijack host cell metabolism and acquire existing nutrient and energy store. The role of the cellular energy sensor AMP-activated protein kinase (AMPK) in the regulation of cellular energy homeostasis is well documented. Here, we highlight recent advances showing the importance of AMPK signaling in pathogen-host interactions. Pathogens interact with AMPK by a variety of mechanisms aimed at reprogramming host cell metabolism to their own benefit. Stimulation of AMPK activity provides an efficient process to rapidly adapt pathogen metabolism to the major nutritional changes often encountered during the different phases of infection. However, inhibition of AMPK is also used by pathogens to manipulate innate host response, indicating that AMPK appears relevant to restriction of pathogen infection. We also document the effects of pharmacological AMPK modulators on pathogen proliferation and survival. This review illustrates intricate pathogen-AMPK interactions that may be exploited to the development of novel anti-pathogen therapies. | por |
dc.description.sponsorship | This work was supported by grants from INSERM, CNRS and Universite Paris Descartes. BV and MF are working in the Departement Hospitalo-Universitaire (DHU) AUToimmune and HORmonal diseaseS. JE acknowledges the support of the Canada Research Chair program. JE and ABC received funding from the European Community's Seventh Framework Programme under grant agreement No. 602773 (Project KINDRED). DM is supported by SFRH/BD/91543/2012. RS thank FCT-Foundation for Science and Technology-for their Investigator FCT Grant (IF/00021/2014). | por |
dc.language.iso | eng | por |
dc.publisher | Bentham Science Publishers | por |
dc.rights | closedAccess | por |
dc.subject | AMP-Activated Protein Kinases | por |
dc.subject | Animals | por |
dc.subject | Anti-Infective Agents | por |
dc.subject | Communicable Diseases | por |
dc.subject | Energy Metabolism | por |
dc.subject | Enzyme Activation | por |
dc.subject | Homeostasis | por |
dc.subject | Host-Pathogen Interactions | por |
dc.subject | Humans | por |
dc.subject | Immunity, Innate | por |
dc.subject | Parasites | por |
dc.subject | Phosphorylation | por |
dc.subject | Protein Interaction Maps | por |
dc.subject | Signal Transduction | por |
dc.subject | Bacterial Physiological Phenomena | por |
dc.subject | Virus Physiological Phenomena | por |
dc.subject | Bacteria | por |
dc.subject | Infectious diseases | por |
dc.subject | Pathogens | por |
dc.subject | Pharmacological drugs | por |
dc.subject | Therapeutics | por |
dc.subject | Virus | por |
dc.subject | AMPK-activated protein kinase | por |
dc.title | AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes? | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.eurekaselect.com/130416/article | por |
oaire.citationStartPage | 942 | por |
oaire.citationEndPage | 953 | por |
oaire.citationIssue | 8 | por |
oaire.citationVolume | 17 | por |
dc.identifier.eissn | 1873-5592 | - |
dc.identifier.doi | 10.2174/1389450116666150416120559 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 25882224 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Current Drug Targets | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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0010J.pdf Acesso restrito! | 1,21 MB | Adobe PDF | Ver/Abrir |