Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62516
Título: | Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy |
Autor(es): | Riera-Domingo, Carla Audigé, Annette Granja, Sara Costa Cheng, Wan-Chen Ho, Ping-Chih Baltazar, Fátima Stockmann, Christian Mazzone, Massimiliano |
Palavras-chave: | cancer hypoxia immunometabolism immunotherapy metabolism |
Data: | 2020 |
Editora: | American Physiological Society |
Revista: | Physiological Reviews |
Citação: | Riera-Domingo, C., Audigé, A., et. al.(2019). Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy. Physiological reviews, 100(1), 1-102. |
Resumo(s): | It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The major aims of this review are to provide an overview on the immune system in cancer; to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; to define how immunotherapies affect hypoxia/oxygen delivery and the metabolic landscape of the tumor; and vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62516 |
DOI: | 10.1152/physrev.00018.2019 |
ISSN: | 0031-9333 |
e-ISSN: | 1522-1210 |
Versão da editora: | https://www.physiology.org/doi/abs/10.1152/physrev.00018.2019 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Riera-Domingo 2019.pdf | 3,11 MB | Adobe PDF | Ver/Abrir |