Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/63452
Título: | Immune parameters for diagnosis and treatment monitoring in invasive mold infection |
Autor(es): | Jenks, Jeffrey D. Rawlings, Stephen A Garcia-Vidal, Carol Koehler, Philipp Mercier, Toine Prattes, Juergen Lass-Flörl, Cornelia Martin-Gomez, M Teresa Buchheidt, Dieter Pagano, Livio Gangneux, Jean-Pierre van de Veerdonk, Frank L. Netea, Mihai G. Carvalho, Agostinho Hoenigl, Martin |
Palavras-chave: | Aspergillus invasive aspergillosis invasive mold infections immune response Mucormycosis prognosis mold-reactive T-cells interleukin 6 interleukin 8 interleukin 10 |
Data: | 2019 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Journal of Fungi |
Citação: | Jenks, J.D.; Rawlings, S.A.; Garcia-Vidal, C.; Koehler, P.; Mercier, T.; Prattes, J.; Lass-Flörl, C.; Martin-Gomez, M.T.; Buchheidt, D.; Pagano, L.; Gangneux, J.-P.; van de Veerdonk, F.L.; Netea, M.G.; Carvalho, A.; Hoenigl, M., on behalf of ECMM working group Immunologic Markers for Treatment Monitoring and Diagnosis in Invasive Mold Infection; Immune Parameters for Diagnosis and Treatment Monitoring in Invasive Mold Infection. J. Fungi 2019, 5, 116. |
Resumo(s): | Infections caused by invasive molds, including Aspergillus spp., can be difficult to diagnose and remain associated with high morbidity and mortality. Thus, early diagnosis and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals with invasive mold infections. Diagnosis remains difficult due to low sensitivities of diagnostic tests including culture and other mycological tests for mold pathogens, particularly in patients on mold-active antifungal prophylaxis. As a result, antifungal treatment is rarely targeted and reliable markers for treatment monitoring and outcome prediction are missing. Thus, there is a need for improved markers to diagnose invasive mold infections, monitor response to treatment, and assist in determining when antifungal therapy should be escalated, switched, or can be stopped. This review focuses on the role of immunologic markers and specifically cytokines in diagnosis and treatment monitoring of invasive mold infections. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/63452 |
DOI: | 10.3390/jof5040116 |
ISSN: | 2309-608X |
Versão da editora: | https://www.mdpi.com/2309-608X/5/4/116 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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jof-05-00116.pdf | 251,63 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons