Potencialities of electrospun mats based on PVA/CA for applications as chronic wound dressings

Abstract

Chronic wounds are unable to follow the normal healing steps, taking more than 12 weeks to heal They are characterized by a defective matrix and cell debris impair healing, prolonged inflammation, moisture imbalance and high bacteria amounts Bacterial infections are the main cause behind complications with the healing of chronic wounds. Biodegradable polymeric wound dressings were engineered by electrospinning with a porous fibrous nanostruture resembling the extracellular matrix The goal was to generate dressings with thin fiber diameters that, in the future, will be functionalized with antimicrobial peptides ( with immunoregulatory properties, to prevent bacterial colonization and fight infection.