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https://hdl.handle.net/1822/65968
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Campo DC | Valor | Idioma |
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dc.contributor.author | Wan, Yizao | por |
dc.contributor.author | Yang, Shanshan | por |
dc.contributor.author | Peng, Mengxia | por |
dc.contributor.author | Gama, F. M. | por |
dc.contributor.author | Yang, Zhiwei | por |
dc.contributor.author | Deng, Xiaoyan | por |
dc.contributor.author | Zhou, Jianye | por |
dc.contributor.author | Ouyang, Chenxi | por |
dc.contributor.author | Luo, Honglin | por |
dc.date.accessioned | 2020-07-13T14:02:30Z | - |
dc.date.available | 2020-07-13T14:02:30Z | - |
dc.date.issued | 2020-06-03 | - |
dc.date.submitted | 2020-04 | - |
dc.identifier.citation | Wan, Yizao; Yang, Shanshan; Peng, Mengxia; Gama, F. M.; Yang, Zhiwei; Deng, Xiaoyan; Zhou, Jianye; Ouyang, Chenxi; Luo, Honglin, Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts. Journal of Materials Chemistry B, 8, 5694-5706, 2020 | por |
dc.identifier.issn | 2050-750X | por |
dc.identifier.uri | https://hdl.handle.net/1822/65968 | - |
dc.description.abstract | Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts. Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis. Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts. It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts. Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31. The in vivo tests demonstrate much lower inflammatory response to the BC/CA graft. These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer. | por |
dc.description.sponsorship | National Natural Science Foundation of China (Grant no. 51973058, 31870963, 31760265) and Key Research and Development Program of Jiangxi Province (No. 20192ACB80008) | por |
dc.language.iso | eng | por |
dc.publisher | RSC | por |
dc.rights | openAccess | por |
dc.title | Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlehtml/2020/tb/d0tb01002b | por |
dc.comments | CEB53762 | por |
oaire.citationStartPage | 5694 | por |
oaire.citationEndPage | 5706 | por |
oaire.citationIssue | 26 | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2020-07-13T12:18:13Z | - |
dc.identifier.eissn | 2050-7518 | por |
dc.identifier.doi | 10.1039/D0TB01002B | por |
dc.identifier.pmid | 32510089 | por |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.subject.fos | Engenharia e Tecnologia::Engenharia dos Materiais | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Materials Chemistry B | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53762_1.pdf | 2,24 MB | Adobe PDF | Ver/Abrir |