Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/66145
Título: | Primary humoral immune deficiencies: overlooked mimickers of chronic immune-mediated gastrointestinal diseases in adults |
Autor(es): | Malesza, Ida Judyta Malesza, Michal Krela-Kazmierczak, Iwona Zielinska, Aleksandra Souto, Eliana B. Dobrowolska, Agnieszka Eder, Piotr |
Palavras-chave: | primary immunodeficiency selective IgA deficiency common variable immunodeficiency celiac disease inflammatory bowel disease Crohns disease ulcerative colitis |
Data: | 23-Jul-2020 |
Editora: | MDPI |
Revista: | International Journal of Molecular Sciences |
Citação: | Malesza, Ida Judyta; Malesza, Michal; Krela-Kazmierczak, Iwona; Zielinska, Aleksandra; Souto, Eliana; Dobrowolska, Agnieszka; Eder, Piotr, Primary humoral immune deficiencies: overlooked mimickers of chronic immune-mediated gastrointestinal diseases in adults. International Journal of Molecular Sciences, 21(15), 5223, 2020 |
Resumo(s): | In recent years, the incidence of immune-mediated gastrointestinal disorders, including celiac disease (CeD) and inflammatory bowel disease (IBD), is increasingly growing worldwide. This generates a need to elucidate the conditions that may compromise the diagnosis and treatment of such gastrointestinal disorders. It is well established that primary immunodeficiencies (PIDs) exhibit gastrointestinal manifestations and mimic other diseases, including CeD and IBD. PIDs are often considered pediatric ailments, whereas between 25 and 45% of PIDs are diagnosed in adults. The most common PIDs in adults are the selective immunoglobulin A deficiency (SIgAD) and the common variable immunodeficiency (CVID). A trend to autoimmunity occurs, while gastrointestinal disorders are common in both diseases. Besides, the occurrence of CeD and IBD in SIgAD/CVID patients is significantly higher than in the general population. However, some differences concerning diagnostics and management between enteropathy/colitis in PIDs, as compared to idiopathic forms of CeD/IBD, have been described. There is an ongoing discussion whether CeD and IBD in CVID patients should be considered a true CeD and IBD or just CeD-like and IBD-like diseases. This review addresses the current state of the art of the most common primary immunodeficiencies in adults and co-occurring CeD and IBD. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/66145 |
ISBN: | 1424-6783 |
DOI: | 10.3390/ijms21155223 |
ISSN: | 1422-0067 |
e-ISSN: | 1661-6596 |
Versão da editora: | https://www.mdpi.com/1422-0067/21/15/5223 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53832_1.pdf | 3,32 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons