Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/68940
Título: | Green synthesis of lignin nano- and micro-particles: Physicochemical characterization, bioactive properties and cytotoxicity assessment |
Autor(es): | Freitas, Filipa M. C. Cerqueira, Miguel Ângelo Parente Ribeiro Gonçalves, Catarina Azinheiro, Sarah Garrido-Maestu, Alejandro Vicente, A. A. Pastrana, Lorenzo M. Teixeira, J. A. Michelin, Michele |
Palavras-chave: | Lignocellulose Nanotechnology Antioxidant Biocompatibility Cytotoxicity |
Data: | Nov-2020 |
Editora: | Elsevier 1 |
Revista: | International Journal of Biological Macromolecules |
Citação: | Freitas, Filipa M. C.; Cerqueira, Miguel A.; Gonçalves, Catarina; Azinheiro, Sarah; Garrido-Maestu, Alejandro; Vicente, António A.; Pastrana, Lorenzo M.; Teixeira, José A.; Michelin, Michele, Green synthesis of lignin nano- and micro-particles: Physicochemical characterization, bioactive properties and cytotoxicity assessment. International Journal of Biological Macromolecules, 163, 1798-1809, 2020 |
Resumo(s): | Lignin particles (LPs) have gained prominence due to their biodegradability and bioactive properties. LP production at nano and micro scale produced from organosolv lignin and the understanding of size's effect on their properties is unexplored. This work aimed to produce and characterize lignin nanoparticles and microparticles using a green synthesis process, based on ethanol-solubilized lignin and water. Spherical shape LPs, with a mean size of 75 nm and 215 nm and with a low polydispersity were produced, as confirmed by transmission electron microscopy and dynamic light scattering. LPs thermal stability improved over raw lignin, and the chemical structure of lignin was not affected by the production method. The antimicrobial tests proved that LPs presented a bacteriostatic effect on Escherichiacoli and Salmonella enterica. Regarding the antioxidant potential, LPs had a good antioxidant activity that increased with the reaction time and LPs concentration. LPs also presented an antioxidant effect against intracellular ROS, reducing the intracellular ROS levels significantly. Furthermore, the LPs showed a low cytotoxic effect in Caco-2 cell line. These results showed that LPs at different scales (nano and micro) present biological properties and are safe to be used in different high value industrial sectors, such as biomedical, pharmaceutical and food. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/68940 |
DOI: | 10.1016/j.ijbiomac.2020.09.110 |
ISSN: | 0141-8130 |
Versão da editora: | http://www.elsevier.com/locate/issn/01418130 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54101_1.pdf | 1,7 MB | Adobe PDF | Ver/Abrir |