Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/70044
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Hurle, K. | por |
dc.contributor.author | Oliveira, J. M. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Pina, Sandra Cristina Almeida | por |
dc.contributor.author | Goetz-Neunhoeffer, F. | por |
dc.date.accessioned | 2021-02-04T08:52:35Z | - |
dc.date.available | 2021-02-04T08:52:35Z | - |
dc.date.issued | 2021-01 | - |
dc.date.submitted | 2021-01 | - |
dc.identifier.citation | Hurle K., Oliveira J. M., Reis R. L., Pina S., Goetz-Neunhoeffer F. Ion-doped Brushite Cements for Bone Regeneration, Acta Biomaterialia, doi:10.1016/j.actbio.2021.01.004, 2021 | por |
dc.identifier.issn | 1742-7061 | por |
dc.identifier.uri | https://hdl.handle.net/1822/70044 | - |
dc.description.abstract | Decades of research in orthopaedics has culminated in the quest for formidable yet resorbable biomaterials using bioactive materials. Brushite cements most salient features embrace high biocompatibility, bioresorbability, osteoconductivity, self-setting characteristics, handling, and injectability properties. Such type of materials is also effectively applied as drug delivery systems. However, brushite cements possess limited mechanical strength and fast setting times. By means of incorporating bioactive ions, which are incredibly promising in directing cell fate when incorporated within biomaterials, it can yield biomaterials with superior mechanical properties. Therefore, it is a key to develop fine-tuned regenerative medicine therapeutics. A comprehensive overview of the current accomplishments of ion-doped brushite cements for bone tissue repair and regeneration is provided herein. The role of ionic substitution on the cements physicochemical properties, such as structural, setting time, hydration products, injectability, mechanical behaviour and ion release is discussed. Cell-material interactions, osteogenesis, angiogenesis, and antibacterial activity of the ion-doped cements, as well as its potential use as drug delivery carriers are also presented. | por |
dc.description.sponsorship | This study was funded by the Portuguese Foundation for Science and Technology (FCT) and the German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) for the transnational cooperation FCT/DAAD 2018-2019. The authors also thank the funds provided under the distinctions attributed to JMO (IF/01285/2015) and SP (CEECIND/03673/2017). Furthermore, funding by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG), Grant Nr. HU 2498/1-1; GB 1/22-1, and the Emerging Talents Initiative of the FAU is acknowledged. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | FCT/DAAD 2018-2019 | por |
dc.relation | IF/01285/2015 | por |
dc.relation | CEECIND/03673/2017 | por |
dc.rights | openAccess | por |
dc.subject | Angiogenesis | por |
dc.subject | Bone cements | por |
dc.subject | Brushite | por |
dc.subject | Drug delivery systems | por |
dc.subject | Ionic dopants | por |
dc.subject | Osseointegration | por |
dc.subject | Tissue engineering | por |
dc.subject | Tissue regeneration | por |
dc.title | Ion-doped brushite cements for bone regeneration | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1742706121000052 | por |
dc.comments | http://3bs.uminho.pt/node/20454 | por |
oaire.citationStartPage | 51 | por |
oaire.citationEndPage | 71 | por |
oaire.citationVolume | 123 | por |
dc.date.updated | 2021-02-03T11:08:23Z | - |
dc.identifier.doi | 10.1016/j.actbio.2021.01.004 | por |
dc.identifier.pmid | 33454382 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Acta Biomaterialia | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20454-Ion-doped brushite cements for bone regeneration.pdf | 7 MB | Adobe PDF | Ver/Abrir |