Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/72050

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dc.contributor.authorAndrade, Luciana N.por
dc.contributor.authorCavendish, Mariana S. S.por
dc.contributor.authorCosta, Salvana P. M.por
dc.contributor.authorAmaral, Ricardo G.por
dc.contributor.authorCorrêa, Cristiane B.por
dc.contributor.authorOliveira, Douglas S.por
dc.contributor.authorMorsink, Margreetpor
dc.contributor.authorGokce, Evren H.por
dc.contributor.authorde Albuquerque Junior, Ricardo L. C.por
dc.contributor.authorSouto, Eliana B.por
dc.contributor.authorSeverino, Patriciapor
dc.date.accessioned2021-04-18T15:05:46Z-
dc.date.available2021-04-18T15:05:46Z-
dc.date.issued2020-11-
dc.identifier.citationAndrade, Luciana N.; Cavendish, Mariana S. S.; Costa, Salvana P. M.; Amaral, Ricardo G.; Corrêa, Cristiane B.; Oliveira, Douglas S.; Morsink, Margreet; Gokce, Evren H.; de Albuquerque Junior, Ricardo L. C.; Souto, Eliana; Severino, Patricia, Perillyl alcohol in Solid Lipid Nanoparticles (SLN-PA): Cytotoxicity and antitumor potential in sarcoma 180 mice model. Precision Nanomedicine, 3(5), 686-698, 2020por
dc.identifier.issn2639-9431por
dc.identifier.urihttps://hdl.handle.net/1822/72050-
dc.description.abstractCancer is a group of diseases characterized by the uncontrolled growth of cells. These cells invade organs and tissues by extension or direct dissemination and can spread to other regions of the body. Nanomedicine offers many possibilities to prevent the spread of cancer tissue and help cure the disease. In this work, solid lipid nanoparticles (SLN) were used to encapsulate perillyl alcohol (PA), a volatile monoterpene with proven anticancer activity. Encapsulation of PA into SLN (SLN-PA) is expected to promote controlled release, increase PA bioavailability, and impair the volatility of the monoterpene. SLN-PA prepared by high-shear homogenization showed average particle diameter around 254 nm, polydispersity index ~ 0.35, zeta potential ~ -14.7 mV, and encapsulation efficiency 84.6%. Scanning electron microscope analysis revealed a decrease in crystallinity, suggesting the encapsulation of PA in the SLN, confirming the spherical shape and the loading of the monoterpene in the SLN. In vitro cytotoxicity assays against murine fibroblasts (L929) showed that SLN-PA in both treated doses did not induce any cytotoxicity on non-tumoral cells. In vivo antitumor effect of the SLN-PA was evaluated in sarcoma 180-transplanted mice. The in vivo results demonstrated a significant tumor inhibition rate of 51.76 and 54.49% via intraperitoneal application of SLN-PA at doses of 100 and 200 mg/kg/day (p < 0.05), respective when compared to the negative control (dimethyl sulfoxide). Adverse side effects of SLN-PA were not noticed in the liver, the kidney, or spleen tissue. The developed SLN-PA can be considered as a safe approach for site-specific antitumor effect in vivo, reinterpreting new nanoparticles- based cancer therapy.por
dc.description.sponsorshipThis work was supported by the Banco do Nordeste (grant FUNDECI/2016.0015), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe (Fapitec) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Eliana B. Souto would like to acknowledge the Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) for the project UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020.por
dc.language.isoengpor
dc.publisherAndover Housepor
dc.relationUIDB/04469/2020por
dc.rightsopenAccesspor
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/por
dc.subjectperillyl alcoholpor
dc.subjectmonoterpenespor
dc.subjectsolid lipid nanoparticlespor
dc.subjectantitumor activitypor
dc.subjectsarcoma 180por
dc.subjecttoxicitypor
dc.subjectslnpor
dc.titlePerillyl alcohol in Solid Lipid Nanoparticles (SLN-PA): Cytotoxicity and antitumor potential in sarcoma 180 mice modelpor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttps://precisionnanomedicine.com/por
dc.commentsCEB54369por
oaire.citationStartPage686por
oaire.citationEndPage698por
oaire.citationIssue5por
oaire.citationVolume3por
dc.date.updated2021-04-18T12:14:43Z-
dc.identifier.doi10.33218/001c.17880por
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersion-
sdum.journalPrecision Nanomedicinepor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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