Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/72471

TítuloA heart-breast cancer-on-a-chip platform for disease modeling and monitoring of cardiotoxicity induced by cancer chemotherapy
Autor(es)Lee, Junmin
Mehrotra, Shreya
Zare-Eelanjegh, Elaheh
Rodrigues, Raquel Oliveira
Akbarinejad, Alireza
Ge, David
Amato, Luca
Kiaee, Kiavash
Fang, YongCong
Rosenkranz, Aliza
Keung, Wendy
Mandal, Biman B.
Li, Ronald A.
Zhang, Ting
Lee, HeaYeon
Dokmeci, Mehmet Remzi
Zhang, Yu Shrike
Khademhosseini, Ali
Shin, Su Ryon
Palavras-chaveBreast cancer
Cardiotoxicity
Electrochemical biosensors
iPSC-cardiac tissues
Organs-on-a-chip
Data2021
EditoraWiley-VCH Verlag
RevistaSmall
CitaçãoLee, J., Mehrotra, S., Zare‐Eelanjegh, E., Rodrigues, R. O., et. al. (2021). A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy. Small, 2004258
Resumo(s)Cardiotoxicity is one of the most serious side effects of cancer chemotherapy. Current approaches to monitoring of chemotherapy-induced cardiotoxicity (CIC) as well as model systems that develop in vivo or in vitro CIC platforms fail to notice early signs of CIC. Moreover, breast cancer (BC) patients with preexisting cardiac dysfunctions may lead to different incident levels of CIC. Here, a model is presented for investigating CIC where not only induced pluripotent stem cell (iPSC)-derived cardiac tissues are interacted with BC tissues on a dual-organ platform, but electrochemical immuno-aptasensors can also monitor cell-secreted multiple biomarkers. Fibrotic stages of iPSC-derived cardiac tissues are promoted with a supplement of transforming growth factor-beta 1 to assess the differential functionality in healthy and fibrotic cardiac tissues after treatment with doxorubicin (DOX). The production trend of biomarkers evaluated by using the immuno-aptasensors well-matches the outcomes from conventional enzyme-linked immunosorbent assay, demonstrating the accuracy of the authors' sensing platform with much higher sensitivity and lower detection limits for early monitoring of CIC and BC progression. Furthermore, the versatility of this platform is demonstrated by applying a nanoparticle-based DOX-delivery system. The proposed platform would potentially help allow early detection and prediction of CIC in individual patients in the future.
TipoArtigo
URIhttps://hdl.handle.net/1822/72471
DOI10.1002/smll.202004258
ISSN1613-6810
Versão da editorahttps://onlinelibrary.wiley.com/doi/full/10.1002/smll.202004258
Arbitragem científicayes
AcessoAcesso restrito autor
Aparece nas coleções:CMEMS - Artigos em revistas internacionais/Papers in international journals

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