Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/72609
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Tavares, Lívia A. | por |
dc.contributor.author | Rezende, Allan A. | por |
dc.contributor.author | Santos, Jymmys L. | por |
dc.contributor.author | Estevam, Charles S. | por |
dc.contributor.author | Silva, Ana M. O. | por |
dc.contributor.author | Schneider, Jaderson K. | por |
dc.contributor.author | Cunha, John L. S. | por |
dc.contributor.author | Droppa-Almeida, Daniela | por |
dc.contributor.author | Correia-Neto, Ivan J. | por |
dc.contributor.author | Cardoso, Juliana C. | por |
dc.contributor.author | Severino, Patricia | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.contributor.author | de Albuquerque-Júnior, Ricardo L. C. | por |
dc.date.accessioned | 2021-05-12T09:28:17Z | - |
dc.date.available | 2021-05-12T09:28:17Z | - |
dc.date.issued | 2021-05-09 | - |
dc.identifier.citation | Tavares, Lívia A.; Rezende, Allan A.; Santos, Jymmys L.; Estevam, Charles S.; Silva, Ana M. O.; Schneider, Jaderson K.; Cunha, John L. S.; Droppa-Almeida, Daniela; Correia-Neto, Ivan J.; Cardoso, Juliana C.; Severino, Patricia; Souto, Eliana; de Albuquerque-Júnior, Ricardo L. C., Cymbopogon winterianus essential oil attenuates bleomycin-induced pulmonary fibrosis in a murine model. Pharmaceutics, 13(5), 979, 2021 | por |
dc.identifier.issn | 1999-4923 | por |
dc.identifier.uri | https://hdl.handle.net/1822/72609 | - |
dc.description.abstract | The essential oil of Cymbopogon winterianus (EOCW) is a natural product with antioxidant, anti-inflammatory, and antifibrotic properties. We studied the effect of EOCW in the progression of histological changes of pulmonary fibrosis (PF) in a rodent model. The oil was obtained by hydrodistillation and characterized using gas chromatographymass spectrometry. Intratracheal instillation of bleomycin was performed in 30 rats to induce PF, while Sham animals were subjected to instillation of saline solution. The treatment was performed using daily oral administration of distilled water, EOCW at 50, 100, and 200 mg/kg, and deflazacort (DFC). After 28 days, hemogram and bronchoalveolar lavage fluid (BALF), tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were assayed. Histological grading of PF, immunohistochemical expression of -smooth muscle actin (-SMA), and transforming growth factor- (TGF-) were also analyzed. The EOCW major compounds were found to be citronellal, geraniol, and citronellol. EOCW significantly reduced inflammation in BALF, reduced MDA levels, and increased SOD activity. EOCW attenuated histological grading of PF and reduced immunohistochemical expression of -SMA and TGF- in a dose-dependent way, likely due to the reduction of oxidative stress, inflammation, and TGF--induced myofibroblast differentiation. | por |
dc.description.sponsorship | This research was financed by the Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Sergipe (FAPITEC), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). EBS wishes to acknowledge the sponsorship of the project UIDB/04469/2020 (strategic fund) from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and was co-financed by FEDER, under the Partnership Agreement PT2020. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | UIDB/04469/2020 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | pulmonary fibrosis | por |
dc.subject | terpenes | por |
dc.subject | Wistar rats | por |
dc.subject | myofibroblasts | por |
dc.subject | histological labelling | por |
dc.subject | immunohistochemistry | por |
dc.title | Cymbopogon winterianus essential oil attenuates bleomycin-induced pulmonary fibrosis in a murine model | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/13/5/679 | por |
dc.comments | CEB54423 | por |
oaire.citationStartPage | 979 | por |
oaire.citationIssue | 5 | por |
oaire.citationConferencePlace | Switzerland | - |
oaire.citationVolume | 13 | por |
dc.date.updated | 2021-05-11T23:12:37Z | - |
dc.identifier.doi | 10.3390/pharmaceutics13050679 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Pharmaceutics | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54423_1.pdf | 2,23 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons