Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/73526
Título: | Overcoming multi-resistant leishmania treatment by nanoencapsulation of potent antimicrobials |
Autor(es): | Oliveira, Simone S. C. Ferreira, Carine S. Branquinha, Marta H. Santos, André L. S. Chaud, Marco V. Jain, Sona Cardoso, Juliana C. Kovacevic, Andelka B. Souto, Eliana B. Severino, Patrícia |
Palavras-chave: | Leishmaniasis nanoparticles targeted delivery macrophages clinical trials nanovaccines |
Data: | Ago-2021 |
Editora: | Wiley-Blackwell |
Revista: | Journal of Chemical Technology and Biotechnology |
Citação: | Oliveira, Simone S. C.; Ferreira, Carine S.; Branquinha, Marta H.; Santos, André L. S.; Chaud, Marco V.; Jain, Sona; Cardoso, Juliana C.; Kovacevic, Andelka B.; Souto, Eliana; Severino, Patrícia, Overcoming multi-resistant leishmania treatment by nanoencapsulation of potent antimicrobials. Journal of Chemical Technology and Biotechnology, 96(8), 2123-2140, 2021 |
Resumo(s): | Leishmaniasis corresponds to a group of neglected tropical diseases caused by flagellated protozoa belonging to the Leishmania genus. This widely spread illness is found in over 90 countries in the tropic and sub-tropic regions and also in southern Europe. As parasites exclusively infect the highly phagocytic cells (macrophages), this aspect can be exploited for targeted delivery making use of nanoparticles. Drug-loaded nanoparticles have been proposed to improve the bioavailability of classical drugs commonly in use as standard leishmania therapy, to overcome parasitic resistance and side effects and improve the treatment efficacy. Infected macrophages are expected to recognize drug-loaded nanoparticles which undergo phagocytosis releasing the drug inside macrophages. This approach can further be exploited for the development of nanovaccines. This paper provides an overview of the current disease status worldwide, its classical pharmacological treatments and how these can be improved by the use of featured nanoparticles specific tailored for such a complex disease. Several types of nanoparticles have been proposed while others have already reached clinical trials. This article is protected by copyright. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/73526 |
DOI: | 10.1002/jctb.6633 |
ISSN: | 0268-2575 |
Versão da editora: | http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4660 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54023_1.pdf Acesso restrito! | 1,31 MB | Adobe PDF | Ver/Abrir |