Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/73930
Título: | ViralFP: a web application of viral fusion proteins |
Autor(es): | Moreira, Pedro Sequeira, Ana Pereira, S. Rodrigues, Rúben André Costa Rocha, Miguel Lousa, Diana |
Palavras-chave: | Fusion proteins Fusion peptides Database Web application Machine learning |
Data: | 23-Ago-2021 |
Editora: | Frontiers Media S.A. |
Revista: | Frontiers in Medical Technology |
Citação: | Moreira, Pedro; Sequeira, Ana; Pereira, Sara; Rodrigues, Rúben; Rocha, Miguel; Lousa, Diana, ViralFP: a web application of viral fusion proteins. Frontiers in Medical Technology, 3(722392), 2021 |
Resumo(s): | Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the host cell. Given the importance of these biomolecules, this work presents a centralized database containing the most relevant information on viral fusion proteins, available through a free-to-use web server accessible through the URL <ext-link ext-link-type=uri xlink:href=https://viralfp.bio.di.uminho.pt/ xmlns:xlink=http://www.w3.org/1999/xlink>https://viralfp.bio.di.uminho.pt/</ext-link>. This web application contains several bioinformatic tools, such as Clustal sequence alignment and Weblogo, including as well a machine learning-based tool capable of predicting the location of fusion peptides (the component of fusion proteins that inserts into the host's cell membrane) within the fusion protein sequence. Given the crucial role of these proteins in viral infection, their importance as natural targets of our immune system and their potential as therapeutic targets, this web application aims to foster our ability to fight pathogenic viruses. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/73930 |
DOI: | 10.3389/fmedt.2021.722392 |
ISSN: | 2673-3129 |
Versão da editora: | https://www.frontiersin.org/articles/10.3389/fmedt.2021.722392 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54609_1.pdf | 3,4 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons