Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/73986
Título: | Innovative methodology for marine collagen-chitosan-fucoidan hydrogels production, tailoring rheological properties towards biomedical application |
Autor(es): | Carvalho, Duarte Nuno Gonçalves, C. Oliveira, J. M. Willliams, D. Mearns Spragg, A. Reis, R. L. Silva, Tiago H. |
Palavras-chave: | Cartilage tissue engineering Gel strength Marine biomaterials Marine origin biopolymers Mechanical Properties |
Data: | Ago-2021 |
Editora: | Royal Society of Chemistry |
Revista: | Green Chemistry |
Citação: | Carvalho D. N., Gonçalves C., Oliveira J. M., Willliams D., Mearns Spragg A., Reis R. L., Silva T. H. Innovative methodology for marine collagen-chitosan-fucoidan hydrogels production, tailoring rheological properties towards biomedical application, Green Chemistry, pp. 1-14, doi:10.1039/D1GC02223G, 2021 |
Resumo(s): | Marine polymers such as collagen, chitosan, and fucoidan can be combined to form ionic-linked hydrogel networks towards applications in tissue engineering (TE). The use of greener approaches (as determined by green metrics â E-factor), including the absence of external chemical cross-linking agents, has advantages regarding the potential cytotoxicity. By tailoring the formulation of such an ionic-linked hydrogel, it is possible to fine-tune scaffold biofunctionality. In this study, a comparative study of composite hydrogels was accomplished, seeking to understand the correlation between polymer characteristics and physical behaviour to develop the applicability of this technology in soft-to-hard TE. Parameters such as polymer concentration, molecular weight, polymer-biomaterials bonds, biomaterial structural architecture, pore size, and mechanical rheological properties were directly correlated to the hydrogelâ s formulation. The results highlight that the formulation with greatest potential was the 3-component hydrogel (H12, followed by H10, H11), due to its superior mechanical properties, making it suitable for cartilage TE. This research offers a valuable perspective on hydrogel formulation and a new processing methodology, as well as how tailoring the hydrogel composition influences mechanical behaviour to support selecting the best composition for tissue engineering applications. |
Tipo: | Artigo |
Descrição: | Accepted Manuscript |
URI: | https://hdl.handle.net/1822/73986 |
DOI: | 10.1039/D1GC02223G |
ISSN: | 1463-9270 |
Versão da editora: | https://pubs.rsc.org/en/content/articlelanding/2021/gc/d1gc02223g |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20558-phd-1-article-rheology.pdf Acesso restrito! | 1,45 MB | Adobe PDF | Ver/Abrir |