Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74321
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Campo DC | Valor | Idioma |
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dc.contributor.author | Sánchez-Maldonado, Jose Manuel | por |
dc.contributor.author | Moñiz-Díez, Ana | por |
dc.contributor.author | ter Horst, Rob | por |
dc.contributor.author | Campa, Daniele | por |
dc.contributor.author | Cabrera-Serrano, Antonio José | por |
dc.contributor.author | Martínez-Bueno, Manuel | por |
dc.contributor.author | Garrido-Collado, María del Pilar | por |
dc.contributor.author | Hernández-Mohedo, Francisca | por |
dc.contributor.author | Fernández-Puerta, Laura | por |
dc.contributor.author | López-Nevot, Miguel Ángel | por |
dc.contributor.author | Cunha, Cristina | por |
dc.contributor.author | González-Sierra, Pedro Antonio | por |
dc.contributor.author | Springer, Jan | por |
dc.contributor.author | Lackner, Michaela | por |
dc.contributor.author | Alcazar-Fuoli, Laura | por |
dc.contributor.author | Fianchi, Luana | por |
dc.contributor.author | Aguado, José María | por |
dc.contributor.author | Pagano, Livio | por |
dc.contributor.author | López-Fernández, Elisa | por |
dc.contributor.author | Clavero, Esther | por |
dc.contributor.author | Potenza, Leonardo | por |
dc.contributor.author | Luppi, Mario | por |
dc.contributor.author | Moratalla, Lucia | por |
dc.contributor.author | Solano, Carlos | por |
dc.contributor.author | Sampedro, Antonio | por |
dc.contributor.author | Cuenca-Estrella, Manuel | por |
dc.contributor.author | Lass-Flörl, Cornelia | por |
dc.contributor.author | PCRAGA Study Group, | por |
dc.contributor.author | Canzian, Federico | por |
dc.contributor.author | Loeffler, Juergen | por |
dc.contributor.author | Li, Yang | por |
dc.contributor.author | Einsele, Hermann | por |
dc.contributor.author | Netea, Mihai G. | por |
dc.contributor.author | Vázquez, Lourdes | por |
dc.contributor.author | Carvalho, Agostinho | por |
dc.contributor.author | Jurado, Manuel | por |
dc.contributor.author | Sainz, Juan | por |
dc.date.accessioned | 2021-10-12T10:55:23Z | - |
dc.date.available | 2021-10-12T10:55:23Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Sánchez-Maldonado, J.M.; Moñiz-Díez, A.; ter Horst, R.; Campa, D.; Cabrera-Serrano, A.J.; Martínez-Bueno, M.; Garrido-Collado, M.d.P.; Hernández-Mohedo, F.; Fernández-Puerta, L.; López-Nevot, M.Á.; Cunha, C.; González-Sierra, P.A.; Springer, J.; Lackner, M.; Alcazar-Fuoli, L.; Fianchi, L.; Aguado, J.M.; Pagano, L.; López-Fernández, E.; Clavero, E.; Potenza, L.; Luppi, M.; Moratalla, L.; Solano, C.; Sampedro, A.; Cuenca-Estrella, M.; Lass-Flörl, C.; PCRAGA Study Group; Canzian, F.; Loeffler, J.; Li, Y.; Einsele, H.; Netea, M.G.; Vázquez, L.; Carvalho, A.; Jurado, M.; Sainz, J. Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium. J. Fungi 2021, 7, 4. https://doi.org/10.3390/jof7010004 | por |
dc.identifier.issn | 2309-608X | - |
dc.identifier.uri | https://hdl.handle.net/1822/74321 | - |
dc.description.abstract | Here, we assessed whether 36 single nucleotide polymorphisms (SNPs) within the <i>TNFSF4</i> and <i>MAPKAPK2</i> loci influence the risk of developing invasive aspergillosis (IA). We conducted a two-stage case control study including 911 high-risk patients diagnosed with hematological malignancies that were ascertained through the aspBIOmics consortium. The meta-analysis of the discovery and replication populations revealed that carriers of the <i>TNFSF4</i><sub>rs7526628T/T</sub> genotype had a significantly increased risk of developing IA (<i>p</i> = 0.00022). We also found that carriers of the <i>TNFSF4</i><sub>rs7526628T</sub> allele showed decreased serum levels of TNFSF14 protein (<i>p</i> = 0.0027), and that their macrophages had a decreased fungicidal activity (<i>p</i> = 0.048). In addition, we observed that each copy of the <i>MAPKAPK2</i><sub>rs12137965G</sub> allele increased the risk of IA by 60% (<i>p</i> = 0.0017), whereas each copy of the <i>MAPKAPK2</i><sub>rs17013271T</sub> allele was estimated to decrease the risk of developing the disease (<i>p</i> = 0.0029). Mechanistically, we found that carriers of the risk <i>MAPKAPK2</i><sub>rs12137965G</sub> allele showed increased numbers of CD38+IgM-IgD- plasmablasts in blood (<i>p</i> = 0.00086), whereas those harboring two copies of the allele had decreased serum concentrations of thymic stromal lymphopoietin (<i>p</i> = 0.00097). Finally, we also found that carriers of the protective <i>MAPKAPK2</i><sub>rs17013271T</sub> allele had decreased numbers of CD27-IgM-IgD- B cells (<i>p</i> = 0.00087) and significantly lower numbers of CD14+ and CD14+CD16- cells (<i>p</i> = 0.00018 and 0.00023). Altogether, these results suggest a role of the <i>TNFSF4 and MAPKAPK2</i> genes in determining IA risk. | por |
dc.description.sponsorship | This study was supported by grants PI20/01845, PI12/02688, and ISCIII-FEDER PI17/02276 from Fondo de Investigaciones Sanitarias (Madrid, Spain), PIM2010EPA-00756 from the ERA-NET PathoGenoMics (0315900A), the Collaborative Research Center/Transregio 124 FungiNet, the Fundacao para a Ciencia e Tecnologia (FCT) (PTDC/SAU-SER/29635/2017, PTDC/MED-GEN/28778/2017, CEECIND/03628/2017, and CEECIND/04058/2018), the European Union's Horizon 2020 research and innovation programme under grant agreement no. 847507, and the "la Caixa" Foundation (ID 100010434) and FCT under the agreement LCF/PR/HP17/52190003). | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | invasive aspergillosis | por |
dc.subject | TNFSF4 | por |
dc.subject | MAPKAPK2 | por |
dc.subject | genetic susceptibility | por |
dc.subject | B cells | por |
dc.subject | monocytes | por |
dc.subject | serum biomarkers | por |
dc.subject | TSLP | por |
dc.subject | TNFSF14 | por |
dc.title | Polymorphisms within the TNFSF4 and MAPKAPK2 Loci influence the risk of developing invasive aspergillosis: A two-stage case control study in the context of the aspBIOmics consortium | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2309-608X/7/1/4 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 17 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2021-01-22T15:47:44Z | - |
dc.identifier.doi | 10.3390/jof7010004 | por |
dc.subject.fos | Ciências Médicas::Ciências da Saúde | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Fungi | por |
oaire.version | VoR | por |
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jof-07-00004-v4.pdf | 1,35 MB | Adobe PDF | Ver/Abrir |
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