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https://hdl.handle.net/1822/74647
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Campo DC | Valor | Idioma |
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dc.contributor.author | Ramos, N. L. P. | por |
dc.contributor.author | Barros, M. | por |
dc.contributor.author | Oliveira, Rui Pedro Soares de | por |
dc.contributor.author | Costa, S. P. G. | por |
dc.contributor.author | Raposo, M. M. M. | por |
dc.date.accessioned | 2021-11-08T10:20:28Z | - |
dc.date.available | 2021-11-08T10:20:28Z | - |
dc.date.issued | 2021-07-14 | - |
dc.identifier.citation | Ramos, N. L. P.; Barros, M.; Oliveira, Rui; Costa, S. P. G.; Raposo, M. M. M., Synthesis and screening of antibacterial activity of 2,4,5-tri(hetero)arylimidazoles based on thieno[3,2-b]thiophene. XXVI National Meeting of the Portuguese Chemical Society - Book of Abstracts. No. F47, Braga, Portugal, July 14-16, 189, 2021. ISBN: 978-989-8124-33-3 | por |
dc.identifier.isbn | 978-989-8124-33-3 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74647 | - |
dc.description.abstract | After the discovery of antibiotics, efforts were made to develop new drugs in order to treat infections caused by a wide range of bacterial strains. With the use of antibiotics for decades, bacteria have adapted, so that resistant strains have emerged. Moreover, the uncontrolled and abusive use of antibiotics has increased, which aggravates the emergence of new resistant strains. The emergence of multidrug resistant (MDR) bacteria has quickly become a worldwide health problem, so new strategies must be developed in order to control MDR bacteria, namely the rational development of new drugs. Imidazole derivatives have several biological activities, including antibacterial activity. In this sense, efforts have been made to develop imidazole-based compounds, because they present higher curative effect than other antibiotics used in clinical practice, lower toxicity and less side effects.1 With this in mind, we report the synthesis of two 2,4,5-tri(hetero)arylimidazoles 3a-b based on thieno[3,2-b]thiophene heterocyclic spacer (Figure 1), through the Radziszewski reaction2 and their characterization by 1H and 13C NMR, UV-Vis absorption and fluorescence spectroscopies. In addition, a screening for antibacterial activity with the synthetized imidazole derivatives against Bacillus subtilis was carried out, using the agar diffusion technique. The results showed the inhibition of Bacillus subtilis proliferation, suggesting antibacterial activity. Therefore, these new imidazole derivatives have the potential for the development of new antibacterial drugs. | por |
dc.description.sponsorship | Thanks are due to Fundação para a Ciência e Tecnologia (FCT) and FEDER (European Fund for Regional Development)-COMPETE-QRENEU for financial support through the Chemistry Research Centre of the University of Minho (UID/QUI/00686/2020). This work was also supported by the “Contrato-Programa” UIDB/04050/2020 funded by national funds through the FCT I.P. Thanks are also due to FCT for financial support to the Portuguese NMR network (PTNMR, Bruker Avance III – Univ. Minho). | por |
dc.language.iso | eng | por |
dc.publisher | Sociedade de Portuguesa de Química (SPQ) | por |
dc.relation | UID/QUI/00686/2020 | por |
dc.relation | UIDB/04050/2020 | por |
dc.rights | openAccess | por |
dc.title | Synthesis and screening of antibacterial activity of 2,4,5-tri(hetero)arylimidazoles based on thieno[3,2-b]thiophene | por |
dc.type | conferenceAbstract | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://xxviienspq.events.chemistry.pt/ | por |
dc.comments | CEB54989 | por |
sdum.event.type | meeting | por |
oaire.citationStartPage | 189 | por |
oaire.citationIssue | F47 | - |
oaire.citationConferencePlace | Braga, Portugal | por |
dc.date.updated | 2021-11-06T12:25:18Z | - |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.conferencePublication | XXVI National Meeting of the Portuguese Chemical Society - Book of Abstracts | por |
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