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https://hdl.handle.net/1822/75755
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Campo DC | Valor | Idioma |
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dc.contributor.author | Gomes, Daniela | por |
dc.contributor.author | Costa, João Manuel Rainha | por |
dc.contributor.author | Rodrigues, L. R. | por |
dc.contributor.author | Rodrigues, Joana Lúcia Lima Correia | por |
dc.contributor.editor | Harzevili, Farshad Darvishi | por |
dc.date.accessioned | 2022-02-02T09:15:26Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Gomes, Daniela; Rainha, João; Rodrigues, Lígia R.; Rodrigues, Joana L., Yeast Synthetic Biology Approaches for the Production of Valuable Polyphenolic Compounds. In Farshad Darvishi Harzevili, Synthetic Biology of Yeasts: Tools and Applications, Springer International Publishing, 2022. ISBN: 978-3-030-89680-5, 119-156 | por |
dc.identifier.isbn | 978-3-030-89679-9 | por |
dc.identifier.uri | https://hdl.handle.net/1822/75755 | - |
dc.description.abstract | Polyphenols are secondary metabolites isolated from plants that are known for their biological and therapeutical properties. However, the extraction from plants renders low yields, besides being expensive and not environmentally friendly. Therefore, the use of heterologous microorganisms, so-called microbial chassis, became an interesting alternative approach to produce polyphenols. With the advances in the metabolic engineering and synthetic biology fields, the development of such microbial chassis able to produce these compounds with higher yields and productivities became easier. Several yeast species, such as Saccharomyces cerevisiae, Yarrowia lipolytica, and Pichia pastoris, have already been engineered to produce some polyphenols. However, there is still a long way to go before these compounds can be produced by heterologous organisms at an industrial scale. In this chapter, we review the recent advances in the production of polyphenolic compounds using yeasts as heterologous hosts, as well as several synthetic biology approaches used to improve such production. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/BIO/04469/2020 unit and BioTecNorte operation (NORTE-01-0145- FEDER-000004) funded by the European Regional Development Fund (ERDF) under the scope of Norte2020—North Portugal Regional Program. DG and JR are recipients of a fellowship supported by a doctoral advanced training (SFRH/BD/04433/2020 and SFRH/BD/138325/2018, respectively) funded by FCT. | por |
dc.language.iso | eng | por |
dc.publisher | Springer International Publishing AG | por |
dc.relation | UIDB/BIO/04469/2020 | por |
dc.relation | SFRH/BD/04433/2020 | por |
dc.relation | SFRH/BD/138325/2018 | por |
dc.rights | closedAccess | por |
dc.title | Yeast synthetic biology approaches for the production of valuable polyphenolic compounds | por |
dc.type | bookPart | por |
dc.peerreviewed | yes | - |
dc.relation.publisherversion | https://link.springer.com/book/10.1007/978-3-030-89680-5 | por |
dc.comments | CEB55240 | por |
oaire.citationStartPage | 119 | por |
oaire.citationEndPage | 156 | por |
oaire.citationConferencePlace | Cham | - |
dc.date.updated | 2022-02-01T22:49:23Z | - |
dc.identifier.doi | 10.1007/978-3-030-89680-5_5 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.eisbn | 978-3-030-89680-5 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.bookTitle | Synthetic biology of yeasts: tools and applications | por |
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