Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/76990
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Couto, Márcia R. | por |
dc.contributor.author | Rodrigues, Joana Lúcia Lima Correia | por |
dc.contributor.author | Rodrigues, L. R. | por |
dc.date.accessioned | 2022-04-19T10:40:51Z | - |
dc.date.available | 2022-04-19T10:40:51Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | Couto, Márcia R.; Rodrigues, Joana L.; Rodrigues, Lígia R., Heterologous production of Chondroitin. Biotechnology Reports, 33(e00710), 2022 | por |
dc.identifier.issn | 2215-017X | por |
dc.identifier.uri | https://hdl.handle.net/1822/76990 | - |
dc.description.abstract | Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources. However, the known risks of animal products use have been driving the search for alternative methods and sources to obtain this compound. Several pathogenic bacteria naturally produce chondroitin-like polysaccharides through well-known pathways and, therefore, have been the basis for numerous studies that aim to produce chondroitin using non-pathogenic hosts. However, the yields obtained are not enough to meet the high demand for this glycosaminoglycan. Metabolic engineering strategies have been used to construct improved heterologous hosts. The identification of metabolic bottlenecks and regulation points, and the screening for efficient enzymes are key points for constructing microbial cell factories with improved chondroitin yields to achieve industrial CS production. The recent advances on enzymatic and microbial strategies to produce non-animal chondroitin are herein reviewed. Challenges and prospects for future research are also discussed. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit. The authors acknowledge FCT for funding the doctoral grant SFRH/BD/132998/2017 to Couto, M. R. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier B.V. | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F132998%2F2017/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | por |
dc.subject | Chondroitin | por |
dc.subject | Glycosaminoglycans | por |
dc.subject | Biosynthetic pathway | por |
dc.subject | Metabolic engineering | por |
dc.subject | Microbial fermentation | por |
dc.subject | Heterologous production | por |
dc.title | Heterologous production of Chondroitin | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.journals.elsevier.com/biotechnology-reports | por |
dc.comments | CEB55288 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 33 | por |
dc.date.updated | 2022-02-19T10:38:58Z | - |
dc.identifier.doi | 10.1016/j.btre.2022.e00710 | por |
dc.subject.fos | Humanidades::Filosofia, Ética e Religião | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.journal | Biotechnology Reports | por |
oaire.version | P | por |
dc.identifier.articlenumber | e00710 | por |
dc.subject.ods | Educação de qualidade | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55288_1.pdf | 2,23 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons