Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/77567

TitleSupramolecular ultra-short carboxybenzyl-protected dehydropeptide-based hydrogels for drug delivery
Author(s)Veloso, Sérgio R. S.
Jervis, Peter J.
Silva, Joana F. G.
Hilliou, L.
Moura, C.
Pereira, David M
Coutinho, Paulo J. G.
Martins, J. A.
Castanheira, Elisabete M. S.
Ferreira, Paula M. T.
KeywordsDrug Carriers
Drug Delivery Systems
Drug Liberation
Curcumin
Hydrogels
Carboxybenzyldehydropeptides
Self-assembly
Supramolecular hydrogels
Drug delivery
Issue dateMar-2021
PublisherElsevier
JournalMaterials Science and Engineering: C
CitationVeloso, S. R. S., Jervis, P. J., Silva, J. F. G., Hilliou, L., Moura, C., Pereira, D. M., . . . Ferreira, P. M. T. (2021). Supramolecular ultra-short carboxybenzyl-protected dehydropeptide-based hydrogels for drug delivery. Materials Science and Engineering: C, 122, 111869. doi: https://doi.org/10.1016/j.msec.2021.111869
Abstract(s)Self-assembled peptide-based hydrogels are promising materials for biomedical research owing to biocompatibility and similarity to the extracellular matrix, amenable synthesis and functionalization and structural tailoring of the rheological properties. Wider developments of self-assembled peptide-based hydrogels in biomedical research and clinical translation are hampered by limited commercial availability allied to prohibitive costs. In this work a focused library of Cbz-protected dehydrodipeptides Cbz-L-Xaa-Z-ΔPhe-OH (Xaa= Met, Phe, Tyr, Ala, Gly) was synthesised and evaluated as minimalist hydrogels. The Cbz-L-Met-Z-ΔPhe-OH and Cbz-L-Phe-Z-ΔPhe-OH hydrogelators were comprehensively evaluated regarding molecular aggregation and self-assembly, gelation, biocompatibility and as drug carriers for delivery of the natural compound curcumin and the clinically important antitumor drug doxorubicin. Drug release profiles and FRET studies of drug transport into small unilamellar vesicles (as biomembrane models) demonstrated that the Cbz-protected dehydropeptide hydrogels are effective nanocarriers for drug delivery. The expedite and scalable synthesis (in 3 steps), using commercially available reagents and amenable reaction conditions, makes Cbz-protected dehydrodipeptide hydrogels, widely available at affordable cost to the research community.
TypeArticle
URIhttps://hdl.handle.net/1822/77567
DOI10.1016/j.msec.2021.111869
ISSN0928-4931
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S0928493121000072
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...)
CDQuim - Artigos (Papers)
IPC - Artigos em revistas científicas internacionais com arbitragem

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