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https://hdl.handle.net/1822/77789
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Campo DC | Valor | Idioma |
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dc.contributor.author | Teixeira, Marta Albertina | por |
dc.contributor.author | Antunes, Joana Isabel Costa | por |
dc.contributor.author | Seabra, Catarina Leal | por |
dc.contributor.author | Fertuzinhos, Aureliano Costa | por |
dc.contributor.author | Tohidi, Shafagh Dinparast | por |
dc.contributor.author | Reis, Salette | por |
dc.contributor.author | Amorim, M. T. Pessoa de | por |
dc.contributor.author | Ferreira, Diana P. | por |
dc.contributor.author | Felgueiras, Helena Prado | por |
dc.date.accessioned | 2022-05-20T21:49:45Z | - |
dc.date.issued | 2022-04-29 | - |
dc.identifier.citation | Teixeira, M. A., Antunes, J. C., Seabra, C. L., Fertuzinhos, A., Tohidi, S. D., Reis, S., . . . Felgueiras, H. P. (2022). Antibacterial and hemostatic capacities of cellulose nanocrystalline-reinforced poly(vinyl alcohol) electrospun mats doped with Tiger 17 and pexiganan peptides for prospective wound healing applications. Biomaterials Advances, 212830. doi: https://doi.org/10.1016/j.bioadv.2022.212830 | por |
dc.identifier.uri | https://hdl.handle.net/1822/77789 | - |
dc.description.abstract | Infection is a major issue in chronic wound care. Different dressings have been developed to prevent microbial propagation, but an effective, all-in-one (cytocompatible, antimicrobial and promoter of healing) solution is still to be uncovered. In this research, polyvinyl alcohol (PVA) nanofibrous mats reinforced with cellulose nanocrystal (CNC), at 10 and 20% v/v ratios, were produced by electrospinning, crosslinked with glutaraldehyde vapor and doped with specialized peptides. Crosslinking increased the mats' fiber diameters but maintained their bead-free morphology. Miscibility between polymers was confirmed by Fourier-transform infrared spectroscopy and thermal evaluations. Despite the incorporation of CNC having reduced the mats' mechanical performance, it improved the mats' surface energy and its structural stability over time. Pexiganan with an extra cysteine group was functionalized onto the mats via hydroxyl- polyethylene glycol 2-maleimide, while Tiger 17 was physisorbed to preserve its cyclic conformation. Antimicrobial assessments demonstrated the peptide-doped mat's effectiveness against Staphylococcus aureus and Pseudomonas aeruginosa; pexiganan contributed mostly for such outcome. Tiger 17 showed excellent capacity in accelerating clotting. Cytocompatibility evaluations attested to these mats' safety. C90/10 PVA/CNC mats were deemed the most effective from the tested group and, thus, a potentially effective option for chronic wound treatments. | por |
dc.description.sponsorship | This research received funding from the Portuguese Foundation for Science and Technology (FCT) under the scope of the projects PTDC/CTM-TEX/28074/2017 (POCI-01-0145-FEDER-028074), PTDC/NANMAT/31444/2017 (POCI-01-0145-FEDER-031444), UID/CTM/00264/2020, UIDB/50006/2020, CEECIND/02803/2017 and SFRH/BD/148930/2019. | por |
dc.description.sponsorship | Authors acknowledge the Portuguese Foundation for Science and Technology (FCT), FEDER funds by means of Portugal 2020 Competitive Factors Operational Program (POCI) and the Portuguese Government (OE) for funding the projects with reference PTDC/CTM-TEX/28074/2017 (POCI-01-0145-FEDER-028074) and PTDC/NANMAT/31444/2017 (POCI-01-0145-FEDER-031444). Authors also acknowledge project UID/CTM/00264/2020 of Centre for Textile Science and Technology (2C2T), funded by national funds through FCT/MCTES. M.A.T. acknowledges FCT for the PhD grant with reference SFRH/BD/148930/2019. The authors acknowledge to the institution LAQV – Laboratório Associado para a Química Verde (UIDB/50006/2020). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FCTM-TEX%2F28074%2F2017/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FNAN-MAT%2F31444%2F2017/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00264%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F02803%2F2017%2FCP1458%2FCT0003/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F148930%2F2019/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Cellulosic compounds | por |
dc.subject | Electrospun mats | por |
dc.subject | Peptide surface functionalization | por |
dc.subject | Adjuvant performance | por |
dc.subject | Improved antimicrobial and clotting effects | por |
dc.title | Antibacterial and hemostatic capacities of cellulose nanocrystalline-reinforced poly(vinyl alcohol) electrospun mats doped with Tiger 17 and pexiganan peptides for prospective wound healing applications | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2772950822001078 | por |
oaire.citationVolume | 137 | por |
dc.identifier.eissn | 2772-9508 | por |
dc.identifier.doi | 10.1016/j.bioadv.2022.212830 | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.fos | Engenharia e Tecnologia::Engenharia Médica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biomaterials Advances | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | DET/2C2T - Artigos em revistas internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2022 Biomaterials Advances.pdf Acesso restrito! | 2,83 MB | Adobe PDF | Ver/Abrir |