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https://hdl.handle.net/1822/79373
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Campo DC | Valor | Idioma |
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dc.contributor.author | Gonçalves, Cristiana | por |
dc.contributor.author | Carvalho, Duarte Nuno | por |
dc.contributor.author | Silva, Tiago H. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Oliveira, Joaquim M. | por |
dc.date.accessioned | 2022-09-01T08:59:43Z | - |
dc.date.available | 2024-04-01T06:01:02Z | - |
dc.date.issued | 2022-03 | - |
dc.date.submitted | 2022-08 | - |
dc.identifier.citation | Gonçalves C., Carvalho D. N., Silva T. H., Reis R. L., Oliveira J. M. Engineering of Viscosupplement Biomaterials for Treatment of Osteoarthritis: A Comprehensive Review, Advanced Engineering Materials, Vol. 24, Issue 8, pp. 2101541 (1 of 16), doi:10.1002/adem.202101541, 2022 | por |
dc.identifier.issn | 1527-2648 | por |
dc.identifier.uri | https://hdl.handle.net/1822/79373 | - |
dc.description.abstract | Osteoarthritis (OA) is a progressive degenerative disease that causes severe pain and functional limitation, especially during locomotion. It is the most common arthritis type that damages the surface of articular cartilage until the underlying bone. In the past decade, the scientific community has made a considerable effort to improve or discover therapeutical products used as a form of conservative treatment capable of restoring the damaged articular tissue, avoiding, as far as possible, the use of surgical practices. The most common and direct nonoperative application available for OA treatment is the viscosupplementation (VS) procedure that demonstrates a safe, effective method and is less painful for the patients. The most recent works dealing with the design, development, and validation of viscosupplement products in preclinical and clinical trials for OA treatment are overviewed herein. In general, despite the development of new products, hyaluronic acid continues to be among the most reported intra-articular viscosupplement products used in clinical trials, typically used as an isolated product or conjugated with other biologicals or drugs, such as platelet-rich plasma and corticosteroids (CS). However, this issue is still demanding innovation. Approaches comprising new biomaterials as VS products, with intrinsic bioactivity, economical, and environmental friendliness, are required. | por |
dc.description.sponsorship | The authors acknowledge the FCT individual financial support (SFRH/BPD/94277/2013, CTTI-58/18-I3Bs(4) and PD/BD/143044/2018) and the financed project PTDC/BTMMAT/29760/2017 (POCI-01-0145-FEDER-029760), by FCT, and cofinanced by FEDER and POCI. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.relation | info:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F94277%2F2013/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F143044%2F2018/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F29760%2F2017/PT | por |
dc.rights | openAccess | por |
dc.subject | Biomaterials | por |
dc.subject | VS | por |
dc.subject | hyaluronic acid | por |
dc.subject | intra-articular injections | por |
dc.subject | knee osteoarthritis | por |
dc.subject | platelet-rich plasma | por |
dc.title | Engineering of viscosupplement biomaterials for treatment of osteoarthritis: A comprehensive review | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/pdf/10.1002/adem.202101541 | por |
dc.comments | http://3bs.uminho.pt/node/20834 | por |
oaire.citationIssue | 8 | por |
oaire.citationVolume | 24 | por |
dc.date.updated | 2022-08-22T10:21:18Z | - |
dc.identifier.doi | 10.1002/adem.202101541 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Advanced Engineering Materials | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20834-adv-eng-mater-2022-goncalves-engineering-viscosupplement-biomaterials-treatment-osteoarthritis.pdf | 2,27 MB | Adobe PDF | Ver/Abrir |