Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80340
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Amorim-de-Sousa, Ana | por |
dc.contributor.author | Schilling, Tim | por |
dc.contributor.author | Fernandes, Paulo | por |
dc.contributor.author | Seshadri, Yeshwanth | por |
dc.contributor.author | Bahmani, Hamed | por |
dc.contributor.author | González-Méijome, José Manuel | por |
dc.date.accessioned | 2022-10-25T17:44:32Z | - |
dc.date.issued | 2021-04-29 | - |
dc.identifier.citation | Amorim-de-Sousa, A., Schilling, T., Fernandes, P., Seshadri, Y., Bahmani, H., & González-Méijome, J. M. (2021). Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes. Scientific Reports, 11(1), 1-10 | por |
dc.identifier.issn | 2045-2322 | por |
dc.identifier.uri | https://hdl.handle.net/1822/80340 | - |
dc.description.abstract | Upregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p<0.001) and 10 min (p<0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for 'Time after stimulation' (p<0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system. | por |
dc.description.sponsorship | This work was supported by the Federal Ministry of Education and Research, Industrie-in-Klinik-Plattform Program BMBF, Germany (FKZ: 13GW0256). This project was also supported by the Portuguese Foundation for Science and Technology (FCT) PTDC/FIS-OPT/0677/2014, the Strategic Funding UID/FIS/04650/2013 at Center of Physics, UMinho, and predoctoral grant SFRH/BD/136684/2018 to AAS. In addition, we would like to thank Nikita Wong for some literature search and language proofreading. | por |
dc.language.iso | eng | por |
dc.publisher | Nature Research | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FFIS%2F04650%2F2013/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FFIS-OPT%2F0677%2F2014/PT | por |
dc.rights | openAccess | por |
dc.title | Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-021-88459-2 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 11 | por |
dc.date.updated | 2022-10-25T14:58:39Z | - |
dc.identifier.eissn | 2045-2322 | por |
dc.identifier.doi | 10.1038/s41598-021-88459-2 | por |
dc.identifier.pmid | 33927248 | - |
dc.subject.fos | Ciências Naturais::Ciências Físicas | por |
dc.subject.wos | Science & Technology | - |
sdum.export.identifier | 12400 | - |
sdum.journal | Scientific Reports | por |
Aparece nas coleções: | CDF - OCV - Artigos/Papers (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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5.5.170. AMORIM-DE-SOUSA_21_b-wave blue light.pdf | 1,25 MB | Adobe PDF | Ver/Abrir |