Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/80974

TitleExploring Xylella fastidiosas metabolic traits using a GSM model of the phytopathogenic bacterium
Author(s)Oliveira, Alexandre Rafael Machado
Cunha, Emanuel Rodrigues
Silva, Miguel
Faria, Cristiana Silva
Dias, Oscar
KeywordsXylella fastidiosa
GSM modelling
Essentially analysis
Merlin
Issue date2022
PublisherSpringer
CitationOliveira, Alexandre; Cunha, Emanuel; Silva, Miguel; Faria, Cristiana; Dias, Oscar, Exploring Xylella fastidiosas Metabolic Traits Using a GSM Model of the Phytopathogenic Bacterium. Lecture Notes in Networks and Systems, Vol. 553, Springer Science and Business Media Deutschland GmbH, 2022. ISBN: 9783030862602
Abstract(s)Xylella fastidiosa is a gram-negative phytopathogenic bacterium able to infect over 500 plant species, with devastating consequences for agricultural and forest-based economies. In the last decade, genome-scale metabolic (GSM) models have become important systems biology tools for studying the metabolic behaviour of different organisms. In this work, a GSM model of X. fastidiosa subsp. pauca De Donno is presented, comprising 1164 reactions, 1379 metabolites, and 508 genes. The model was validated by comparing in silico simulations with available experimental data. The GSM model allowed identifying potential drug targets using a pipeline based on a gene essentiality analysis of the model.
TypeBook part
DescriptionThe model presented in this work can be found in BioModels [26] with the identifier MODEL2205020002. To access the model: – Visit https://www.ebi.ac.uk/biomodels/login/auth. – Log in with the username reviewerForMODEL2205020002 and password DEMPB4. – Access https://www.ebi.ac.uk/biomodels/MODEL2205020002 to view the model.
URIhttps://hdl.handle.net/1822/80974
ISBN9783030862602
DOI10.1007/978-3-031-17024-9_8
ISSN2367-3370
Publisher versionhttps://link.springer.com/bookseries/15179
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CEB - Livros e Capítulos de Livros / Books and Book Chapters

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