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https://hdl.handle.net/1822/80974| Title: | Exploring Xylella fastidiosas metabolic traits using a GSM model of the phytopathogenic bacterium |
| Author(s): | Oliveira, Alexandre Rafael Machado Cunha, Emanuel Rodrigues Silva, Miguel Faria, Cristiana Silva Dias, Oscar |
| Keywords: | Xylella fastidiosa GSM modelling Essentially analysis Merlin |
| Issue date: | 2022 |
| Publisher: | Springer |
| Citation: | Oliveira, Alexandre; Cunha, Emanuel; Silva, Miguel; Faria, Cristiana; Dias, Oscar, Exploring Xylella fastidiosas Metabolic Traits Using a GSM Model of the Phytopathogenic Bacterium. Lecture Notes in Networks and Systems, Vol. 553, Springer Science and Business Media Deutschland GmbH, 2022. ISBN: 9783030862602 |
| Abstract(s): | Xylella fastidiosa is a gram-negative phytopathogenic bacterium able to infect over 500 plant species, with devastating consequences for agricultural and forest-based economies. In the last decade, genome-scale metabolic (GSM) models have become important systems biology tools for studying the metabolic behaviour of different organisms. In this work, a GSM model of X. fastidiosa subsp. pauca De Donno is presented, comprising 1164 reactions, 1379 metabolites, and 508 genes. The model was validated by comparing in silico simulations with available experimental data. The GSM model allowed identifying potential drug targets using a pipeline based on a gene essentiality analysis of the model. |
| Type: | Book part |
| Description: | The model presented in this work can be found in BioModels [26] with the identifier MODEL2205020002. To access the model: – Visit https://www.ebi.ac.uk/biomodels/login/auth. – Log in with the username reviewerForMODEL2205020002 and password DEMPB4. – Access https://www.ebi.ac.uk/biomodels/MODEL2205020002 to view the model. |
| URI: | https://hdl.handle.net/1822/80974 |
| ISBN: | 9783030862602 |
| DOI: | 10.1007/978-3-031-17024-9_8 |
| ISSN: | 2367-3370 |
| Publisher version: | https://link.springer.com/bookseries/15179 |
| Peer-Reviewed: | yes |
| Access: | Restricted access (UMinho) |
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Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| document_55916_1.pdf Restricted access | 333,13 kB | Adobe PDF | View/Open |
