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https://hdl.handle.net/1822/82063
Título: | Poly(lactic-co-glycolide) based biodegradable electrically and magnetically active microenvironments for tissue regeneration applications |
Autor(es): | Hermenegildo, B. Meira, Rafaela Marques Correia, D. M. Díez, A. G. Ribeiro, Sylvie Oliveira Serra, J. P. Ribeiro C. Pérez-Álvarez, L. Vilas-Vilela, José L. Lanceros-Méndez, S. |
Palavras-chave: | Magnetic and ionic materials Poly(lactic-co-glycolide) Electrospun membranes Tissue engineering |
Data: | 2022 |
Editora: | Elsevier |
Revista: | European Polymer Journal |
Resumo(s): | Polymer scaffolds are playing an increasing role in tissue engineering (TE), although there is still a need to improve their biomimicry of cellular microenvironments, by having smart scaffolds with an active response, which can improve tissue regeneration. This work reports on the novel combination of poly(lactic-co-glycolide) (PLGA) with the ionic liquid (IL) choline bis(trifluoromethylsulfonyl)imide ([Chol][TFSI]) or with iron oxide nanoparticles (Fe3O4, NP) in order to achieve biodegradable scaffolds with electroactive and magnetoactive response, respectively. The composites were processed into fiber and film morphologies. PLGA + IL fibers present diameters between 1.92 and 3.26 µm, decreased mechanical stiffness and elongation at yield with respect to the pristine polymer, and some fiber concentrations are not biocompatible. PLGA + IL films present a mean roughness 6.58 nm, increased mechanical stiffness with respect to the pristine polymer and decreased elongation at yield. The inclusion of IL increased the electrical conductivity of the polymer by 4 orders or magnitude.The diameter of PLGA + Fe3O4 fibers ranged from 0.62 to 1.36 µm, show an effective magnetic NP content yield between 52 and 78%, decreased stiffness and increased elongation at yield. PLGA + Fe3O4 films show a mean roughness of 5.07 nm, effective NP content yield between 77 and 97%, increased stiffness and elongation at yield. Cytotoxicity assays indicate that the PLGA + Fe3O4 materials are suitable for biomedical applications, independently of the filler content and morphology, whereas the IL containing samples are non-cytotoxic only in film morphology up to 5% wt. IL content. Finally, it is demonstrated that dynamic magneto mechanical stimulation of the PLGA + Fe3O4 samples allows the acceleration of the degradation rate of the samples. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/82063 |
DOI: | 10.1016/j.eurpolymj.2022.111197 |
ISSN: | 0014-3057 |
e-ISSN: | 1873-1945 |
Versão da editora: | https://doi.org/10.1016/j.eurpolymj.2022.111197 |
Arbitragem científica: | yes |
Acesso: | Acesso embargado (2 Anos) |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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45.pdf Até 2025-01-01 | 2,05 MB | Adobe PDF | Ver/Abrir |