Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85090
Título: | Glycopeptide-based supramolecular hydrogels induce differentiation of adipose stem cells into neural lineages |
Autor(es): | Castro, Vânia Isabel Baptista Araújo, Ana Rita Rodrigues Duarte, Filipa Sousa-Franco, António Reis, R. L. Pashkuleva, I. Pires, R. A. |
Palavras-chave: | Glycopeptide Plycopeptide Neural tissue Stem cells differentiation Supramolecular Hydrogels stem cell differentiation |
Data: | Jun-2023 |
Editora: | ACS Publications |
Revista: | ACS Applied Materials and Interfaces |
Citação: | Castro V. I. B., Araújo A. R., Duarte F., Sousa-Franco A., Reis R. L., Pashkuleva I., Pires R. A. Glycopeptide-based supramolecular hydrogels induce differentiation of adipose stem cells into neural lineages, Acs Applied Materials & Interfaces, doi:10.1021/acsami.3c05309, 2023 |
Resumo(s): | We applied a bottom-up approach to develop biofunctional supramolecular hydrogels from an aromatic glycodipeptide. The self-assembly of the glycopeptide was induced by either temperature manipulation (heatingâ cooling cycle) or solvent (DMSO to water) switch. The solâ gel transition was salt-triggered in cell culture media and resulted in gels with the same chemical compositions but different mechanical properties. Human adipose derived stem cells (hASCs) cultured on these gels under basal conditions (i.e., without differentiation factors) overexpressed neural markers, such as GFAP, Nestin, MAP2, and βIII-tubulin, confirming the differentiation into neural lineages. The mechanical properties of the gels influenced the number and distribution of the adhered cells. A comparison with gels obtained from the nonglycosylated peptide showed that glycosylation is crucial for the biofunctionality of the hydrogels by capturing and preserving essential growth factors... |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/85090 |
DOI: | 10.1021/acsami.3c05309 |
ISSN: | 1944-8244 |
Versão da editora: | https://doi.org/10.1021/acsami.3c05309 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20942-acsami3c05309.pdf | 5,83 MB | Adobe PDF | Ver/Abrir |