Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/88825Registo completo
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Freitas, Ruben | por |
| dc.contributor.author | Rodrigues, Manuel | por |
| dc.contributor.author | Pimenta, Sara Filomena Ribeiro | por |
| dc.contributor.author | Belsley, M. | por |
| dc.contributor.author | Correia, J. H. | por |
| dc.contributor.author | Maciel, Marino Jesus Correia | por |
| dc.date.accessioned | 2024-02-19T11:31:02Z | - |
| dc.date.issued | 2024 | - |
| dc.identifier.citation | Freitas, R., Rodrigues, M., pimenta, . sara ., Belsley, M., Correia, J., & Maciel, M. (2024, January 15). Highly-selective optical filter for NADH fluorescence detection in multiphoton microscopy. Biomedical Optics Express. Optica Publishing Group. http://doi.org/10.1364/boe.506777 | por |
| dc.identifier.uri | https://hdl.handle.net/1822/88825 | - |
| dc.description.abstract | Colorectal cancer (CRC) is a pressing global health concern, emphasizing the need for early detection tools. In this study an optical filter for precise detection of nicotinamide adenine dinucleotide (NADH) fluorescence via two-photon excitation fluorescence (TPEF) was developed. Fabricated with silicon dioxide and titanium dioxide thin films in a Fabry-Perot structure, the filter achieved a peak transmittance of about 95% at 483 nm, with a 12 nm fullwidth at half maximum. TPEF measurements using a tailored setup and NADH liquid phantoms underscored the filter's significance in selectively capturing NADH fluorescence while mitigating interference from other fluorophores. This work marks a substantial stride towards integrating multiphoton microscopy into conventional colonoscopy, enabling noninvasive, objective optical biopsy for colorectal tissue analysis. Further refinements of the experimental setup are imperative to advance tissue differentiation and enhance CRC diagnosis. | por |
| dc.description.sponsorship | This work is supported by: MPhotonBiopsy, PTDC/FISOTI/1259/2020, http://doi.org/10.54499/PTDC/FIS-OTI/1259/2020; CMEMS-UMinho Strategic Project UIDB/04436/2020 and UIDP/04436/2020. Ruben B. Freitas thank FCT for the Ph.D. grant 2021.06966.BD. Sara Pimenta thanks FCT for the grant 2022.00101.CEECIND/CP1718/CT0008, ttps://doi.org/10.54499/2022.00101.CEECIND/CP1718/CT0008. The authors thank P. Lundgren from TU Chalmers for paper reading and revision. | por |
| dc.language.iso | eng | por |
| dc.publisher | Optica | por |
| dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FFIS-OTI%2F1259%2F2020/PT | por |
| dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04436%2F2020/PT | por |
| dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04436%2F2020/PT | por |
| dc.relation | 2021.06966.BD | por |
| dc.relation | CEECIND/CP1718/CT0008 | por |
| dc.rights | closedAccess | por |
| dc.title | Highly-selective optical filter for NADH fluorescence detection in multiphoton microscopy | por |
| dc.type | article | por |
| dc.peerreviewed | yes | por |
| dc.relation.publisherversion | https://opg.optica.org/boe/abstract.cfm?doi=10.1364/BOE.506777 | por |
| dc.identifier.eissn | 2156-7085 | por |
| dc.identifier.doi | 10.1364/BOE.506777 | por |
| dc.date.embargo | 10000-01-01 | - |
| dc.subject.fos | Engenharia e Tecnologia::Engenharia Médica | por |
| sdum.journal | Biomedical Optics Express | por |
| oaire.version | AM | por |
| dc.subject.ods | Saúde de qualidade | por |
| Aparece nas coleções: | CMEMS - Artigos em revistas internacionais/Papers in international journals | |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| AcceptedManuscript.pdf Acesso restrito! | 621,62 kB | Adobe PDF | Ver/Abrir |
