Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/91152
Título: | Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted treatment of hepatocellular carcinoma via the oral route |
Autor(es): | Gao, Qiang Chen, Nanx Li, Baoyi Zu, Menghang Ma, Ya Xu, Haiting Zhu, Zhenhua Reis, R. L. Kundu, Subhas C Xiao, Bo |
Palavras-chave: | Galactose-mediated endocytosis Green preparation Liver cancer Natural nanomedicine Oral route |
Data: | 2024 |
Editora: | BMC |
Revista: | Journal of Nanobiotechnology |
Citação: | Gao Q., Chen N., Li B., Zu M., Ma Y., Xu H., Zhu Z., Reis R. L., Kundu S. C., Xiao B. Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted treatment of hepatocellular carcinoma via the oral route, Journal Of Nanobiotechnology, Vol. 22, Issue 4, 1477-3155, 2024 |
Resumo(s): | The clinical application of conventional medications for hepatocellular carcinoma treatment has been severely restricted by their adverse effects and unsatisfactory therapeutic effectiveness. Inspired by the concept of â medicine food homologyâ , we extracted and purified natural exosome-like lipid nanoparticles (LNPs) from black mulberry (Morus nigra L.) leaves. The obtained MLNPs possessed a desirable hydrodynamic particle size (162.1 nm), a uniform size distribution (polydispersity indexâ =â 0.025), and a negative surface charge (-26.6 mv). These natural LNPs were rich in glycolipids, functional proteins, and active small molecules (e.g., rutin and quercetin 3-O-glucoside). In vitro experiments revealed that MLNPs were preferentially internalized by liver tumor cell lines via galactose receptor-mediated endocytosis, increased intracellular oxidative stress, and triggered mitochondrial damage, resulting in suppressing the viability, migration, and invasion of these cells. Importantly, in vivo investigations suggested that oral MLNPs entered into the circulatory system mainly through the jejunum and colon, and they exhibited negligible adverse effects and superior anti-liver tumor outcomes through direct tumor killing and intestinal microbiota modulation. These findings collectively demonstrate the potential of MLNPs as a natural, safe, and robust nanomedicine for oral treatment of hepatocellular carcinoma. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/91152 |
DOI: | 10.1186/s12951-023-02286-3 |
ISSN: | 1477-3155 |
Versão da editora: | https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-023-02286-3 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21153-s12951-023-02286-3.pdf | 20,64 MB | Adobe PDF | Ver/Abrir |