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https://hdl.handle.net/1822/91610
Título: | Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut |
Autor(es): | Gaifem, Joana Mendes-Frias, Ana Wolter, Mathis Steimle, Alex Garzón, Maria Jose Ubeda, Carles Nobre, Clarisse González, Abigail Pinho, Salomé S. Cunha, Cristina Amorim Carvalho, Agostinho Castro, António Gil Desai, Mahesh S. Rodrigues, Fernando José dos Santos Silvestre, Ricardo Jorge Leal |
Palavras-chave: | Akkermansia muciniphila Parabacteroides distasonis Colitis Microbiome ILC Gut immunity |
Data: | 12-Mar-2024 |
Editora: | American Society for Microbiology |
Revista: | mbio |
Citação: | Gaifem, Joana; Mendes-Frias, Ana; Wolter, Mathis; Steimle, Alex; Maria Jose Garzón; Ubeda, Carles; Nobre, Clarisse; Colunga, Alondra; Pinho, Salomé S.; Cunha, Cristina; Carvalho, Agostinho; Castro, António Gil; Desai, Mahesh S.; Rodrigues, Fernando; Silvestre, Ricardo, Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut. mBio, 15(4), 1-24, 2024 |
Resumo(s): | The contribution of the gut microbiome to the balance between homeostasis and inflammation is widely known. Nevertheless, the etiology of inflammatory bowel disease, which is known to be influenced by genetics, immune response, and environmental cues, remains unclear. Unlocking novel players involved in the dictation of a protective gut, namely, in the microbiota component, is therefore crucial to develop novel strategies to tackle IBD. Herein, we revealed a synergistic interaction between two commensal bacterial strains, Akkermansia muciniphila and Parabacteroides distasonis, which induce protection against both acute and chronic models of colitis induction, by enhancing epithelial barrier integrity and promoting group 3 innate lymphoid cells in the colonic mucosa. This study provides a novel insight on how commensal bacteria can beneficially act to promote intestinal homeostasis, which may open new avenues toward the use of microbiome-derived strategies to tackle IBD. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/91610 |
DOI: | 10.1128/mbio.00078-24 |
ISSN: | 2161-2129 |
Versão da editora: | http://mbio.asm.org/ |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_57782_1.pdf Acesso restrito! | 5,13 MB | Adobe PDF | Ver/Abrir |