Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/13244
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Campo DC | Valor | Idioma |
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dc.contributor.author | Bessa, Paulo C. | - |
dc.contributor.author | Machado, Raul | - |
dc.contributor.author | Nürnberger, Sylvia | - |
dc.contributor.author | Dopler, Daniela | - |
dc.contributor.author | Banerjee, Asmita | - |
dc.contributor.author | Cunha, A. M. | - |
dc.contributor.author | Rodríguez-Cabello, José Carlos | - |
dc.contributor.author | Redl, Heinz | - |
dc.contributor.author | Griensven, Martijn van | - |
dc.contributor.author | Reis, R. L. | - |
dc.contributor.author | Casal, Margarida | - |
dc.date.accessioned | 2011-08-01T16:04:21Z | - |
dc.date.available | 2011-08-01T16:04:21Z | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 0168-3659 | por |
dc.identifier.uri | https://hdl.handle.net/1822/13244 | - |
dc.description.abstract | Elastin-like polymers are a new type of protein-based polymers that display interesting properties in the biomaterial field. Bone morphogenetic proteins (BMPs) are cytokines with a strong ability to promote new bone formation. In this work, we explored the use of elastin-like nanoparticles (average size 237.5±3.0 nm), created by thermoresponsive self-assembly, for the combined release of bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-14 (BMP-14). These BMPs could be encapsulated at high efficiency into the elastin-like particles and delivered in a sustained way for 14 days. The activity of the growth factors was retained, as shown by the induction of ALP activity and osteogenic mineralization in C2C12 cells. Increased bioactivity was observed with a combined release of BMP-2 and BMP-14. This approach shows a significant potential for future tissue engineering applications in bone. | por |
dc.description.sponsorship | This work was supported by Fundacao para a Ciencia e Tecnologia (PhD grants SFRH/BD/17049/2004 and SFRH/BD/36754/2007), project ElastM POCI/CTM/57177/2004 funded by FEDER and Fundacao para a Ciencia e Tecnologia; Marie Curie Alea Jacta EST short-term grant (MEST-CT-2004-8104) and European STREP Project HIPPOCRATES (NMP3-CT-2003-505758). This work was carried out under the scope of the European NoE EXPERTISSUES (NMP3-CT-2004-500283). We acknowledge financial support from the MICINN (projects MAT 2007-66275-C02-01, NAN2004-08538, and PSE-300100-2006-1), the JCyL (projects VA034A09, VA016B08, and VA030A08), the CIBER-BBN (project CB06-01-0003), the JCyL and the Instituto de Salud Carlos III under the "Network Center of Regenerative Medicine and Cellular Therapy of Castilla and Leon". | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | restrictedAccess | por |
dc.subject | Elastin-like polymer | por |
dc.subject | Thermoresponsive | por |
dc.subject | Delivery | por |
dc.subject | Nanoparticles | por |
dc.subject | BMP-2 | por |
dc.subject | BMP-14 | por |
dc.title | Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/ | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 312 | por |
oaire.citationEndPage | 318 | por |
oaire.citationIssue | 3 | por |
oaire.citationTitle | Journal of controlled release | por |
oaire.citationVolume | 142 | por |
dc.identifier.doi | 10.1016/j.jconrel.2009.11.003 | por |
dc.identifier.pmid | 19913578 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of controlled release | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals IPC - Artigos em revistas científicas internacionais com arbitragem |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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9_AMC_JControlled Release.pdf Acesso restrito! | 1 MB | Adobe PDF | Ver/Abrir |