Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/13845
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Campo DC | Valor | Idioma |
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dc.contributor.author | Silva, Raquel | - |
dc.contributor.author | Little, Collin | - |
dc.contributor.author | Ferreira, Helena | - |
dc.contributor.author | Paulo, Artur Cavaco | - |
dc.date.accessioned | 2011-10-12T08:28:16Z | - |
dc.date.available | 2011-10-12T08:28:16Z | - |
dc.date.issued | 2008-09 | - |
dc.date.submitted | 2007 | - |
dc.identifier.issn | 1350-4177 | por |
dc.identifier.uri | https://hdl.handle.net/1822/13845 | - |
dc.description.abstract | This study presents the highlights of ultrasonic effects on peptides incorporated on phospholipid aggregates (liposomes). These liposomes or vesicles are known as transport agents in skin drug delivery and for hair treatment. They might be a good model to deliver larger peptides into hair to restore fibre strength after hair coloration, modelling, permanent wave and/or straightening. The preparation of liposomes 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC) with peptides (LLLLK LLLLK LLLLK LLLLK; LLLLL LCLCL LLKAK AK) was made by the thin film hydration method. The LUVs (uni-lamellar vesicles) were obtained by sonication, applying different experimental conditions, such as depth (mm) and power intensity (%). Photon-correlation spectroscopy (PCS) and electronic microscopy (EM) results confirmed that the incorporation of these peptides, with different sequence of amino acids, presented differences on the diameter, zeta-potential of membrane surface and shape of liposomes. The liposomes that included peptide LLLLK LLLLK LLLLK LLLLK present an increased in zeta-potential values after using ultrasound and an “amorphous” aspect. Conversely, the liposomes that incorporated the peptide LLLLL LCLCL LLKAK AK presented a define shape (rod shape) and the potential surface of liposome did not change significantly by the use of ultrasound. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | Liposome | por |
dc.subject | Ultrasound radiation | por |
dc.subject | Peptides | por |
dc.subject | Photon-correlation | por |
dc.subject | Spectroscopy | por |
dc.subject | Zeta-potential | por |
dc.subject | Electronic microscopy | por |
dc.subject | photon-correlation spectroscopy | por |
dc.title | Incorporation of peptides in phospholipid aggregates using ultrasound | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S1350417708000461 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1026 | por |
oaire.citationEndPage | 1032 | por |
oaire.citationIssue | 6 | por |
oaire.citationTitle | Ultrasonics Sonochemistry | por |
oaire.citationVolume | 15 | por |
dc.identifier.doi | 10.1016/j.ultsonch.2008.03.010 | por |
dc.identifier.pmid | 18467154 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Ultrasonics Sonochemistry | por |
Aparece nas coleções: | DET/2C2T - Artigos em revistas internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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INCORPORATION OF PEPTIDES IN PHOSPHOLIPID AGGREGATES USING ULTRASOUND.pdf | Incorporation of peptides in phospholipid aggregates using ultrasound | 2 MB | Adobe PDF | Ver/Abrir |