Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/15115
Título: | Synthesis of 3-indolylazoles and meridianin derivatives from indolyl enaminonitriles |
Autor(es): | Campos, Ana M. F. Oliveira Salaheldin, Abdellatif M. Paz, Filipe A. Almeida Rodrigues, Lígia M. |
Palavras-chave: | Indole Alkaloids Enaminonitrile Meridianins 3-Indolylazoles |
Data: | 29-Nov-2011 |
Editora: | ARKAT USA, Inc. |
Revista: | Arkivoc |
Resumo(s): | The reaction of indole derivatives with cyanoacetic acid followed by treatment with DMFDMA gave the intermediate indolyl enaminonitriles (3). Further reaction with aminoguanidine yielded 5´-cyanomeridianin analogues (4). The same intermediate reacted with p-methoxyphenylhydrazine to give the pyrazolyl derivative (8). Treatment of (2E)-3-dimethylamino-2-(1H-indol-3-yl)-propenoate (3a) with hydroxylamine hydrochloride in basic medium afforded (5-amino-isoxazol-4-yl)-(1H-indol-3-yl)-methanone (5) and the acrylic acid derivative (6) after a short or a long heating, respectively. Unequivocal structural elucidation of the latter compound was achieved from single-crystal X-ray diffraction studies. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/15115 |
DOI: | 10.3998/ark.5550190.0012.b11 |
ISSN: | 1551-7012 |
Versão da editora: | http://www.arkat-usa.org/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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synthesis of 3-indolylazoles-2.pdf | documento principal | 300,25 kB | Adobe PDF | Ver/Abrir |