Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/16761
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Machado, C. D. | - |
dc.contributor.author | Costa, Rafael S. | - |
dc.contributor.author | Rocha, Miguel | - |
dc.contributor.author | Rocha, I. | - |
dc.contributor.author | Tidor, Bruce | - |
dc.contributor.author | Ferreira, Eugénio C. | - |
dc.date.accessioned | 2012-02-02T16:55:04Z | - |
dc.date.available | 2012-02-02T16:55:04Z | - |
dc.date.issued | 2010 | - |
dc.date.submitted | 02-07-2010 14:24:28 | por |
dc.identifier.isbn | 978-972-8692-53-7 | - |
dc.identifier.issn | 1613-0073 | por |
dc.identifier.uri | https://hdl.handle.net/1822/16761 | - |
dc.description.abstract | The different modeling approaches in Systems Biology create models with different levels of detail. The transformation techniques in Petri net theory can provide a solid framework for zooming between these different levels of abstraction and refinement. This work presents a Petri net based approach to Metabolic Engineering that implements model reduction methods to reduce the complexity of large-scale metabolic networks. These methods can be complemented with kinetics inference to build dynamic models with a smaller number of parameters. The central carbon metabolism model of E. coli is used as a test-case to illustrate the application of these concepts. Model transformation is a promising mechanism to facilitate pathway analysis and dynamic modeling at the genome-scale level. | por |
dc.description.sponsorship | (undefined) | por |
dc.language.iso | eng | por |
dc.rights | openAccess | por |
dc.title | Model transformation of metabolic networks using a Petri net based framework | por |
dc.type | conferencePaper | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 101 | por |
oaire.citationEndPage | 115 | por |
oaire.citationTitle | International Workshop on Biological Processes & Petri Nets (BioPPN 2010)) | por |
oaire.citationVolume | 827 | por |
sdum.journal | CEUR Workshop Proceedings | por |
sdum.conferencePublication | International Workshop on Biological Processes & Petri Nets (BioPPN 2010)) | por |
Aparece nas coleções: | CEB - Artigos em Livros de Atas / Papers in Proceedings |