Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/18637
Título: | Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours |
Autor(es): | Oliveira, Antônio Talvane Torres Reis, R. M. Afonso, Julieta Alexandra Pereira Martinho, Olga Matos, Delcio Carvalho, André Lopes Vazquez, Vinícius Lima Silva, Thiago Buosi Scapulatempo-Neto, Cristovam Saad, Sarhan Sydney Longatto Filho, Adhemar |
Palavras-chave: | Gastrointestinal stromal tumours KIT D2-40 VEGF-C VEGFR-3 |
Data: | Nov-2011 |
Editora: | Universidad de Murcia |
Revista: | Histology and Histopathology |
Resumo(s): | This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD assessment) and CD31 (for blood vessel density – BDV – assessment). The results were correlated with the clinical-pathological data. The large majority of cases (86.2%; 44/51) showed a mutation of the KIT gene, most of them (72.5%; 37/51) revealing mutations in exon 11. VEGFR-3 was predominantly expressed in KIT mutated GISTs (p=0.019). High LVD was correlated with the absence of metastasis (p=0.010) and high BVD showed a positive correlation with the occurrence of metastasis (p=0.049). The strong expression of VEGF-C and VEGFR-3 in GIST’s cells was not correlated with the clinical parameters of aggressiveness, nor with high LVD. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/18637 |
ISSN: | 0213-3911 |
Versão da editora: | http://www.hh.um.es/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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de Oliveira AT_ Histol Histopathol 2011.pdf | Documento principal | 1,51 MB | Adobe PDF | Ver/Abrir |