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https://hdl.handle.net/1822/18686
Título: | Epigenetic (de)regulation of adult hippocampal neurogenesis : implications for depression |
Autor(es): | Pinheiro, António Mateus Pinto, Luísa Sousa, Nuno |
Palavras-chave: | Adult neurogenesis Depression Epigenetics Antidepressants Dentate gyrus hippocampus |
Data: | Nov-2011 |
Editora: | BioMed Central (BMC) |
Revista: | Clinical Epigenetics |
Resumo(s): | Adult neurogenesis represents a dynamic level of modulation upon the neuroplastic properties of the mature nervous system, that is essential to the homeostatic brain function. The adult neurogenic process comprises several sequential steps, all of which subjected to an assortment of cell-intrinsic and neurogenic-niche complex regulatory mechanisms. Among these, epigenetic regulation is now emerging as a crucial regulator of several neurogenesis steps. In particular, the active regulation of hippocampal neurogenesis and its repercussions in global hippocampal function are of special interest for the biomedical field, since imbalances at this level have been strongly related to the precipitation of several neuropsychyatric disorders, such as depression. Indeed, growing evidence supports that the detrimental effects on adult hippocampal neurogenesis, that have been associated with depression, might be epigenetically mediated. Therefore, understanding the epigenetic regulation of the neurogenic process may provide a link between neurogenesis imbalances and the deterioration of the behavioural and cognitive domains frequently affected in depression, thus contributing to unravel the complex pathophysiology of this disorder. Here, we outline some of the major epigenetic mechanisms contributing to the regulation of hippocampal neurogenesis and discuss several lines of evidence supporting their involvement on the development of imbalances in the neurogenic process, often correlated to behavioural and cognitive deficits commonly observed in major depressive disorder. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/18686 |
DOI: | 10.1186/1868-7083-3-5 |
ISSN: | 1868-7075 |
Versão da editora: | http://www.clinicalepigeneticsjournal.com/content/3/1/5 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Mateus-Pinheiro A_ Clinical epigenetics 2011.pdf | Documento principal | 1,4 MB | Adobe PDF | Ver/Abrir |