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https://hdl.handle.net/1822/18765
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Carvalho, Ana Raquel Franky Gomes | - |
dc.contributor.author | Bockstaele, Elisabeth J. Van | - |
dc.date.accessioned | 2012-04-19T16:06:47Z | - |
dc.date.available | 2012-04-19T16:06:47Z | - |
dc.date.issued | 2011 | - |
dc.date.submitted | 2011-08-01 | - |
dc.identifier.issn | 0304-3940 | por |
dc.identifier.uri | https://hdl.handle.net/1822/18765 | - |
dc.description.abstract | The cannabinoid system is known to interact with a variety of neuromodulators in the central nervous system and impacts diverse behaviors. Previous studies have demonstrated that limbic norepinephrine is a critical determinant in the behavioral expression of cannabinoid-induced aversion. The present study was carried out to define the adrenergic receptor subtype involved in mediating cannabinoid-induced behavioral responses. An acute microinjection of the 1-adrenergic receptor blocker, betaxolol, directly into the nucleus accumbens (Acb), was able to prevent WIN 55,212-2-induced aversion, but not lithium-induced aversion, as measured in a place conditioning paradigm. These results suggest that noradrenergic transmission in the Acb is important for cannabinoid-induced aversion and that beta-adrenergic antagonists may be effective in counteracting negative side effects of cannabinoid-based agents. | por |
dc.description.sponsorship | This work was supported by PHS grant DA 020129. Ana Franky Carvalho was supported by the Portuguese Foundation for Science and Technology (SFRH/BD/33236/2007) | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | Cannabinoids | por |
dc.subject | Lithium | por |
dc.subject | Adrenergic receptors | por |
dc.subject | Place conditioning | por |
dc.subject | Aversion | por |
dc.title | Direct intra-accumbal infusion of a beta-adrenergic receptor antagonist abolishes WIN 55,212-2-induced aversion | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0304394011009025 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 82 | por |
oaire.citationEndPage | 85 | por |
oaire.citationIssue | 1 | por |
oaire.citationTitle | Neuroscience Letters | por |
oaire.citationVolume | 500 | por |
dc.identifier.doi | 10.1016/j.neulet.2011.06.008 | por |
dc.identifier.pmid | 21693171 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Neuroscience Letters | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Carvalho AF_Neurosc Lett-pp 2011.pdf | Versão preprint | 558,47 kB | Adobe PDF | Ver/Abrir |