Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/19351
Título: | The use of ionic liquids in the processing of chitosan/silk hydrogels for biomedical applications |
Autor(es): | Silva, Simone Santos Santos, T. C. Cerqueira, M. T. Marques, A. P. Reys, L. L. Silva, Tiago H. Caridade, S. G. Mano, J. F. Reis, R. L. |
Palavras-chave: | Ionic liquids Silk fibroin Chitosan Hydrogels |
Data: | 2012 |
Editora: | Royal Society of Chemistry |
Revista: | Green Chemistry |
Resumo(s): | Natural polymers are adequate renewable resources for the processability of well-defined architectures for several applications. Combinations of polysaccharides and proteins may mimic the naturally occurring environment of certain tissues. The main goal of this work renders the application of green chemistry principles, namely the use of ionic liquids (ILs) and biorenewable sources, such as chitosan (CHT) and silkfibroin (SF), to process new hydrogel-based constructs. Although the solubilization of both materials in ILs has been studied individually, this work reports, for the first time, the role of ILs as solvent, for the production of hydrogels from blends of chitosan and silkfibroin (CSF). These systems offer the advantage of being homogeneous and presenting easy and short dissolution time of both biomacromolecules. Moreover, the use of chitosan obtained fromα- andβ-chitin allowed the production of blended hydrogels with distinct physical–chemical properties.In vitroassays demonstrated that these hydrogels supported the adhesion and growth of primary human dermalfibroblasts. Taken these properties together, the CSF hydrogels might be promising biomaterials to be explored for skin tissue engineering approaches. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/19351 |
DOI: | 10.1039/c2gc16535j |
ISSN: | 1463-9270 |
Versão da editora: | http://pubs.rsc.org/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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published.PDF | Documento principal | 1,65 MB | Adobe PDF | Ver/Abrir |