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https://hdl.handle.net/1822/20564
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Grenha, Ana | - |
dc.contributor.author | Gomes, Manuela E. | - |
dc.contributor.author | Rodrigues, Márcia T. | - |
dc.contributor.author | Santo, Vitor E. | - |
dc.contributor.author | Mano, J. F. | - |
dc.contributor.author | Neves, N. M. | - |
dc.contributor.author | Reis, R. L. | - |
dc.date.accessioned | 2012-10-26T16:58:04Z | - |
dc.date.available | 2012-10-26T16:58:04Z | - |
dc.date.issued | 2010 | - |
dc.date.submitted | 2009-01 | - |
dc.identifier.issn | 1549-3296 | por |
dc.identifier.uri | https://hdl.handle.net/1822/20564 | - |
dc.description.abstract | The use of polymeric nanoparticles, especially those composed of natural polymers, has become a very interesting approach in drug delivery., mainly because of the advantages offered by their small dimensions. The aim of this work was to develop a novel formulation of nanoparticles comprised of two natural marine-derived polymers, namely chitosan and carrageenan, and to evaluate their potential for the association and controlled release of macromolecules. Nanoparticles were obtained in a hydrophilic environment, under very mild conditions, avoiding the use of organic solvents or other aggressive technologies for their preparation. The developed nanocarriers presented sizes within 350-650 run and positive zeta potentials of 50-60 mV. Polymeric interactions between nanoparticles' components were evaluated by Fourier transform infrared spectroscopy. Using ovalbumin as model protein, nanoparticles evidenced loading capacity varying from 4% to 17%, and demonstrated excellent capacity to provide a controlled release for up to 3 weeks. Furthermore, nanoparticles have demonstrated to exhibit a noncytotoxic behavior in biological in vitro tests performed using L929 fibroblasts, which is critical regarding the biocompatibility of those carriers. In summary, the developed chitosan-carrageenan nanoparticles have shown promising properties to be used as carriers of therapeutic macromolecules, with potential application not only strictly in drug delivery, but also in broader areas, such as tissue engineering and regenerative medicine. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 1265-1272, 2010 | por |
dc.description.sponsorship | Contract grant sponsor: Portuguese Foundation for Science and Technology (FCT) (POCTI/FEDER programmes)Contract grant sponsor: European Union STREP Project HIPPOCRATES; contract grant number: NMP3-CT-2003505758Contract grant sponsor: European NoE EXPERTISSUES; contract grant number: NMP3-CT-2004-500283 | por |
dc.language.iso | eng | por |
dc.publisher | John Wiley and Sons | por |
dc.rights | openAccess | por |
dc.subject | carrageenan | por |
dc.subject | chitosan | por |
dc.subject | controlled release | por |
dc.subject | ionic interaction | por |
dc.subject | nanoparticles | por |
dc.title | Development of new chitosan/carrageenan nanoparticles for drug delivery applications | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1265 | por |
oaire.citationEndPage | 1272 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 92A | por |
dc.identifier.doi | 10.1002/jbm.a.32466 | por |
dc.identifier.pmid | 19322874 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Biomedical Materials Research: Part A | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |