Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/20589
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Oliveira, Joaquim M. | - |
dc.contributor.author | Salgado, A. J. | - |
dc.contributor.author | Sousa, Nuno | - |
dc.contributor.author | Mano, J. F. | - |
dc.contributor.author | Reis, R. L. | - |
dc.date.accessioned | 2012-10-29T18:19:26Z | - |
dc.date.available | 2012-10-29T18:19:26Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 0079-6700 | por |
dc.identifier.uri | https://hdl.handle.net/1822/20589 | - |
dc.description.abstract | Since the pioneering work dealing with the synthesis and physicochemical aspects of dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and imaging systems has been reported. These are well documented, butmanyhot issues should be examined and reviewed. Herein, a review is given on dendritic nanopolymers and their applications that show promise in the field of regenerative medicine. This review begins with a brief overview on research merging nanotechnology and regenerative medicine. Fundamentals of the synthesis and macromolecular structure of dendritic polymers are provided. Dendrimers fulfill the requirements as carriers for gene, nucleic acids, bioactive molecules and peptide/protein delivery aimed at modulate the cells functions, in vitro and in vivo. However, to make use of this potential, toxicological, drug-loading capacity, surface engineering and host–guest chemistries in dendrimers must be addressed and thus are also discussed. We focus on recent work involving dendrimers with applications in tissue engineering and the central nervous system. Due to their innovative character, applications beyond drug delivery systems became possible, namely as scaffolding and chemoattractants for tissue regeneration, and implantable biodegradable nanomaterialbased medical devices integrated with drug delivery functions (theranostics). Finally, we highlight promising areas for further research and comment on how and why dendrimer and dendron technology should be viewed as the next generation of biomaterials for the 21st century. | por |
dc.description.sponsorship | The authors wish to acknowledge the funding provided by the Portuguese Foundation for Science and Technology (FCT) through the POCTI and FEDER programs, and FCT project (SMARTCARBO). This work was carried out under the scope of the European NoE EXPERTISSUES (NMP3-CT-2004-500283) and European Union HIPPOCRATES STREP Project (NMP3-CT-2003-505758). Canon Foundation in Europe is also gratefully acknowledged. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | Central nervous system | por |
dc.subject | Dendrimers | por |
dc.subject | Drug delivery systems | por |
dc.subject | Regenerative medicine | por |
dc.subject | Tissue engineering | por |
dc.subject | Theranostics | por |
dc.title | Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S1359644604032763 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1163 | por |
oaire.citationEndPage | 1194 | por |
oaire.citationIssue | 9 | por |
oaire.citationTitle | Progress in Polymer Science | por |
oaire.citationVolume | 35 | por |
dc.identifier.doi | 10.1016/j.progpolymsci.2010.04.006 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Progress in Polymer Science | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals ICVS - Artigos em revistas internacionais / Papers in international journals |