Multilayers as 3D nanostructured porous constructs

Abstract

In this work, the authors propose to explore the binding potential of nonostructured multilayers produced by layer-bylayer self-assembly based on perfusion technique, which was otherwise limited to coating only. Random spherical wax templates of same size were transformed into moldable soft three-dimensional (3D) core material with different external geometries. Placement of template spheres with different sizes by sequential stacking along multiple space axes in a single construct induced internal variations leading to different patterns. Stable porous interconnected nanostructured soft 3D macroconstructs made of natural based polyelectrolytes with a controlled external shape and different internal patterns were developed after removing wax template. Such highly porous structures with hierarchical organization could be used, for example, as scaffolds for tissue engineering applications.