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https://hdl.handle.net/1822/25531Registo completo
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Leitão, Alexandre F. | - |
| dc.contributor.author | Gupta, Swati | - |
| dc.contributor.author | Silva, João P. | - |
| dc.contributor.author | Reviakine, I. | - |
| dc.contributor.author | Gama, F. M. | - |
| dc.date.accessioned | 2013-10-07T12:01:49Z | - |
| dc.date.available | 2013-10-07T12:01:49Z | - |
| dc.date.issued | 2013 | - |
| dc.identifier.issn | 0927-7765 | por |
| dc.identifier.uri | https://hdl.handle.net/1822/25531 | - |
| dc.description.abstract | Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC–blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE – used as a point of comparison – thus evidencing their suitability for cardiovascular applications. | por |
| dc.description.sponsorship | Funding for this work was made possible by the FCT fund-ing through the project PTDC/EBB-EBI/112170/2009, FCT PhDgrant (SFRH/BD/66094/2009) and COST-Short Term Mission (COST-STSM-TD1003-8978). Additionally, funding from the Departmentof Industry of the Basque Government program ETORTEK and fromthe Spanish Ministry of Science and Innovation (basic researchgrant CTQ2009-11245 to IR) are also gratefully acknowledged. | por |
| dc.language.iso | eng | por |
| dc.publisher | Elsevier 1 | por |
| dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/112170/PT | - |
| dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F66094%2F2009/PT | - |
| dc.rights | openAccess | por |
| dc.subject | Bacterial cellulose | por |
| dc.subject | Biocompatibility | por |
| dc.subject | Biomaterials | por |
| dc.subject | Polyvinyl alcohol | por |
| dc.subject | Platelets | por |
| dc.subject | Hemocompatibility | por |
| dc.title | Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite | por |
| dc.type | article | por |
| dc.peerreviewed | yes | por |
| dc.relation.publisherversion | www.elsevier.com/locate/colsurfb | por |
| sdum.publicationstatus | published | por |
| oaire.citationStartPage | 493 | por |
| oaire.citationEndPage | 502 | por |
| oaire.citationTitle | Colloids and Surfaces B: Biointerfaces | por |
| oaire.citationVolume | 111 | por |
| dc.publisher.uri | Elsevier BV | por |
| dc.identifier.eissn | 0927-7765 | por |
| dc.identifier.doi | 10.1016/j.colsurfb.2013.06.031 | - |
| dc.identifier.pmid | 23880088 | por |
| dc.subject.wos | Science & Technology | por |
| sdum.journal | Colloids and Surfaces B: Biointerfaces | por |
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