Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/28433
Título: | Yeast stress, aging, and death |
Autor(es): | Mazzoni, Cristina Giannattasio, Sergio Winderickx, Joris Ludovico, Paula |
Data: | 2013 |
Editora: | Hindawi Publishing Corporation |
Revista: | Oxidative Medicine and Cellular Longevity |
Resumo(s): | [Excerpt] Until about 15 years ago, programmed cell death (PCD), at that time mainly defined as apoptosis, was believed to be a feature occurring only in metazoans to ensure proper embryonic development, cell differentiation, and regulation of the immune response. However, the discovery that single-celled organisms, such as yeast, also undergo PCD challenged this idea. Meanwhile, several key regulators and cell death executers were shown to be highly conserved in yeast and other unicellular organisms, and it is now generally accepted that at least part of the molecular cell death machinery originated early in evolution. Approximately 31% of the yeast genes have a mammalian homologue, and an additional 30% of yeast genes show domain similarity. This, combined with the ease of manipulation of yeast and the elegance of yeast genetics, has turned this lower eukaryote into an ideal system to study more complex phenomena that occur in metazoan cells, including stress responses, mechanisms governing life span and cell death, and processes contributing to aging or human diseases like cancers and neurodegenerative disorders. In this special issue, we collected both original research and review articles, which combined give a nice overview on the current status of the field. (...) |
Tipo: | Editorial em revista |
URI: | https://hdl.handle.net/1822/28433 |
DOI: | 10.1155/2013/684395 |
ISSN: | 1942-0994 |
Versão da editora: | http://www.hindawi.com/journals/omcl/2013/684395/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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mazzoni c_oxid med cell longev 2013.pdf | 1,36 MB | Adobe PDF | Ver/Abrir |