Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/28455
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Kimura, Tetsuya | - |
dc.contributor.author | Whitcomb, Daniel J. | - |
dc.contributor.author | Jo, Jihoon | - |
dc.contributor.author | Regan, Philip | - |
dc.contributor.author | Piers, Thomas | - |
dc.contributor.author | Heo, Seonghoo | - |
dc.contributor.author | Brown, Christopher | - |
dc.contributor.author | Hashikawa, Tsutomu | - |
dc.contributor.author | Murayama, Miyuki | - |
dc.contributor.author | Seok, Heon | - |
dc.contributor.author | Sotiropoulos, I. | - |
dc.contributor.author | Kim, Eunjoon | - |
dc.contributor.author | Collingridge, Graham L. | - |
dc.contributor.author | Takashima, Akihiko | - |
dc.contributor.author | Cho, Kwangwook | - |
dc.date.accessioned | 2014-03-20T14:14:57Z | - |
dc.date.available | 2014-03-20T14:14:57Z | - |
dc.date.issued | 2014 | - |
dc.date.submitted | 2014-02 | - |
dc.identifier.issn | 0962-8436 | por |
dc.identifier.uri | https://hdl.handle.net/1822/28455 | - |
dc.description.abstract | The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (LTD) in tau knockout mice in vivo and in vitro, an effect that was replicated by RNAi knockdown of tau in vitro. We found that the induction of LTD is associated with the glycogen synthase kinase-3-mediated phosphorylation of tau. These observations demonstrate that tau has a critical physiological function in LTD. | por |
dc.description.sponsorship | A.T. was supported by the research funding for longevity sciences (23-39) from National Center for Geriatrics and Gerontology, and the Strategic Research Programme for Brain Science ('Integrated Research on Neuropsychiatric Disorders') and Grant in Aid for Scientific Research on Innovative Areas ('Brain Environment') from the Ministry of Education, Science, Sports and Culture of Japan. K.C., D.J.W. and G.L.C. were supported by UK Wellcome Trust-MRC Neurodegenerative Disease Initiative Programme. K.C. was supported by the Korea-UK Alzheimer's Disease Research Consortium programme from the Ministry of Health and Welfare (Korea). G.L.C. was supported by the WCU Programme (Korea). I.S. was supported by the British Council. The collaboration between K.C. and A.T. was supported by a Sasakawa Foundation grant awarded to K.C. K.C. was supported by the Wolfson Research Merit Award and the Royal Society, London. | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society | por |
dc.rights | openAccess | por |
dc.subject | Alzheimer's disease | por |
dc.subject | hippocampus | por |
dc.subject | synaptic plasticity | por |
dc.subject | long-term depression | por |
dc.subject | tau | por |
dc.title | Microtubule-associated protein tau is essential for long-term depression in the hippocampus | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://rstb.royalsocietypublishing.org/ | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 9 | por |
oaire.citationIssue | 1633 | por |
oaire.citationTitle | Philosophical Transactions of the Royal Society B : Biological Sciences | por |
oaire.citationVolume | 369 | por |
dc.date.updated | 2014-03-06T11:03:10Z | - |
dc.identifier.doi | 10.1098/rstb.2013.0144 | - |
dc.identifier.pmid | 24298146 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Philosophical Transactions of the Royal Society B: Biological Sciences | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
kimura t_philos t r soc b 2014 posp.pdf | 996,65 kB | Adobe PDF | Ver/Abrir |